Induction of DNA damage by oxidised amino acids and proteins

Catherine Luxford; Roger T. Dean; Michael J. Davies

doi:10.1023/A:1015228001561

Induction of DNA damage by oxidised amino acids and proteins

Catherine Luxford
, Roger T. Dean
, Michael J. Davies

MARCS Institute for Brain, Behaviour & Development

Research output: Contribution to journal › Article

45 Citations (Scopus)

Abstract

Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO"¢), peroxyl (ROO"¢) and carbon-centred (R"¢) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

Original language	English
Number of pages	8
Journal	Biogerontology
DOIs	https://doi.org/10.1023/A:1015228001561
Publication status	Published - 2002

Open Access - Access Right Statement

Keywords

DNA
DNA damage
oxidation
proteins
radicals

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title = "Induction of DNA damage by oxidised amino acids and proteins",

abstract = "Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO{"}¢), peroxyl (ROO{"}¢) and carbon-centred (R{"}¢) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.",

keywords = "DNA, DNA damage, oxidation, proteins, radicals",

author = "Catherine Luxford and Dean, \{Roger T.\} and Davies, \{Michael J.\}",

year = "2002",

doi = "10.1023/A:1015228001561",

language = "English",

journal = "Biogerontology",

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TY - JOUR

T1 - Induction of DNA damage by oxidised amino acids and proteins

AU - Luxford, Catherine

AU - Dean, Roger T.

AU - Davies, Michael J.

PY - 2002

Y1 - 2002

N2 - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO"¢), peroxyl (ROO"¢) and carbon-centred (R"¢) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

AB - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO"¢), peroxyl (ROO"¢) and carbon-centred (R"¢) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

KW - DNA

KW - DNA damage

KW - oxidation

KW - proteins

KW - radicals

UR - http://handle.uws.edu.au:8081/1959.7/514702

U2 - 10.1023/A:1015228001561

DO - 10.1023/A:1015228001561

M3 - Article

C2 - 12014851

SN - 1389-5729

JO - Biogerontology

JF - Biogerontology

ER -

Induction of DNA damage by oxidised amino acids and proteins

Abstract

Open Access - Access Right Statement

Keywords

Access to Document

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