Influence of active dendrites on firing patterns in a retinal ganglion cell model

Tianruo Guo, David Tsai, Sinisa Sovilj, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

    Research output: Chapter in Book / Conference PaperConference Paperpeer-review

    4 Citations (Scopus)

    Abstract

    ![CDATA[Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.]]
    Original languageEnglish
    Title of host publicationProceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan
    PublisherIEEE
    Pages4577-4560
    Number of pages4
    ISBN (Print)9781457702167
    DOIs
    Publication statusPublished - 2013
    EventIEEE Engineering in Medicine and Biology Society. Conference -
    Duration: 3 Jul 2013 → …

    Publication series

    Name
    ISSN (Print)1557-170X

    Conference

    ConferenceIEEE Engineering in Medicine and Biology Society. Conference
    Period3/07/13 → …

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