Influence of active dendrites on firing patterns in a retinal ganglion cell model

Tianruo Guo; David Tsai; Sinisa Sovilj; John W. Morley; Gregg J. Suaning; Nigel H. Lovell; Socrates Dokos

doi:10.1109/EMBC.2013.6610561

Influence of active dendrites on firing patterns in a retinal ganglion cell model

Tianruo Guo, David Tsai, Sinisa Sovilj, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

School of Medicine

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

5 Citations (Scopus)

Abstract

Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.

Original language	English
Title of host publication	Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan
Publisher	IEEE
Pages	4577-4560
Number of pages	4
ISBN (Print)	9781457702167
DOIs	https://doi.org/10.1109/EMBC.2013.6610561
Publication status	Published - 2013
Event	IEEE Engineering in Medicine and Biology Society. Conference - Duration: 3 Jul 2013 → …

Publication series

Name
ISSN (Print)	1557-170X

Conference

Conference	IEEE Engineering in Medicine and Biology Society. Conference
Period	3/07/13 → …

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10.1109/EMBC.2013.6610561

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Guo, T., Tsai, D., Sovilj, S., Morley, J. W., Suaning, G. J., Lovell, N. H., & Dokos, S. (2013). Influence of active dendrites on firing patterns in a retinal ganglion cell model. In Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan (pp. 4577-4560). IEEE. https://doi.org/10.1109/EMBC.2013.6610561

@inproceedings{52524c8648024042b259afab0b280392,

title = "Influence of active dendrites on firing patterns in a retinal ganglion cell model",

abstract = "Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.",

author = "Tianruo Guo and David Tsai and Sinisa Sovilj and Morley, {John W.} and Suaning, {Gregg J.} and Lovell, {Nigel H.} and Socrates Dokos",

year = "2013",

doi = "10.1109/EMBC.2013.6610561",

language = "English",

isbn = "9781457702167",

publisher = "IEEE",

pages = "4577--4560",

booktitle = "Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan",

note = "IEEE Engineering in Medicine and Biology Society. Conference ; Conference date: 03-07-2013",

}

Guo, T, Tsai, D, Sovilj, S, Morley, JW, Suaning, GJ, Lovell, NH & Dokos, S 2013, Influence of active dendrites on firing patterns in a retinal ganglion cell model. in Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, pp. 4577-4560, IEEE Engineering in Medicine and Biology Society. Conference, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610561

Influence of active dendrites on firing patterns in a retinal ganglion cell model. / Guo, Tianruo; Tsai, David; Sovilj, Sinisa et al.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, 2013. p. 4577-4560.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

TY - GEN

T1 - Influence of active dendrites on firing patterns in a retinal ganglion cell model

AU - Guo, Tianruo

AU - Tsai, David

AU - Sovilj, Sinisa

AU - Morley, John W.

AU - Suaning, Gregg J.

AU - Lovell, Nigel H.

AU - Dokos, Socrates

PY - 2013

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AB - Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.

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UR - http://embc2013.embs.org/index.html

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DO - 10.1109/EMBC.2013.6610561

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EP - 4560

BT - Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan

PB - IEEE

T2 - IEEE Engineering in Medicine and Biology Society. Conference

Y2 - 3 July 2013

ER -

Influence of active dendrites on firing patterns in a retinal ganglion cell model

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