Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes

Richard A. Chudleigh; Gareth Dunseath; Rajesh Peter; John N. Harvey; Richard L. Ollerton; Steve Luzio; David R. Owens

doi:10.2337/dc07-1335

Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes

Richard A. Chudleigh
, Gareth Dunseath
, Rajesh Peter
, John N. Harvey
, Richard L. Ollerton
, Steve Luzio
, David R. Owens

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The American Diabetes Association recommends estimation of glomerular filtration rate (GFR) (1) by either the Cockcroft-Gault (2) or the Modification of Diet in Renal Disease (MDRD) (3) equation in all patients with diabetes. The implication is that these equations provide similar results. Body weight is a numerator in the Cockcroft- Gault equation; however, it is absent from the MDRD equation. This may explain some of the difference in the ability of these equations to estimate GFR in patients with type 2 diabetes, over 80% of whom are obese (4), and may lead to discrepancies in reporting of chronic kidney disease stage (5). Our study was designed to identify whether body weight may explain variability in performance between the Cockcroft-Gault and MDRD equations in patients newly diagnosed with type 2 diabetes.

Original language	English
Pages (from-to)	47-49
Number of pages	3
Journal	Diabetes Care
Volume	31
Issue number	1
DOIs	https://doi.org/10.2337/dc07-1335
Publication status	Published - 2008

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10.2337/dc07-1335

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title = "Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes",

abstract = "The American Diabetes Association recommends estimation of glomerular filtration rate (GFR) (1) by either the Cockcroft-Gault (2) or the Modification of Diet in Renal Disease (MDRD) (3) equation in all patients with diabetes. The implication is that these equations provide similar results. Body weight is a numerator in the Cockcroft- Gault equation; however, it is absent from the MDRD equation. This may explain some of the difference in the ability of these equations to estimate GFR in patients with type 2 diabetes, over 80\% of whom are obese (4), and may lead to discrepancies in reporting of chronic kidney disease stage (5). Our study was designed to identify whether body weight may explain variability in performance between the Cockcroft-Gault and MDRD equations in patients newly diagnosed with type 2 diabetes.",

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T1 - Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes

AU - Chudleigh, Richard A.

AU - Dunseath, Gareth

AU - Peter, Rajesh

AU - Harvey, John N.

AU - Ollerton, Richard L.

AU - Luzio, Steve

AU - Owens, David R.

PY - 2008

Y1 - 2008

N2 - The American Diabetes Association recommends estimation of glomerular filtration rate (GFR) (1) by either the Cockcroft-Gault (2) or the Modification of Diet in Renal Disease (MDRD) (3) equation in all patients with diabetes. The implication is that these equations provide similar results. Body weight is a numerator in the Cockcroft- Gault equation; however, it is absent from the MDRD equation. This may explain some of the difference in the ability of these equations to estimate GFR in patients with type 2 diabetes, over 80% of whom are obese (4), and may lead to discrepancies in reporting of chronic kidney disease stage (5). Our study was designed to identify whether body weight may explain variability in performance between the Cockcroft-Gault and MDRD equations in patients newly diagnosed with type 2 diabetes.

AB - The American Diabetes Association recommends estimation of glomerular filtration rate (GFR) (1) by either the Cockcroft-Gault (2) or the Modification of Diet in Renal Disease (MDRD) (3) equation in all patients with diabetes. The implication is that these equations provide similar results. Body weight is a numerator in the Cockcroft- Gault equation; however, it is absent from the MDRD equation. This may explain some of the difference in the ability of these equations to estimate GFR in patients with type 2 diabetes, over 80% of whom are obese (4), and may lead to discrepancies in reporting of chronic kidney disease stage (5). Our study was designed to identify whether body weight may explain variability in performance between the Cockcroft-Gault and MDRD equations in patients newly diagnosed with type 2 diabetes.

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SP - 47

EP - 49

JO - Diabetes Care

JF - Diabetes Care

IS - 1

ER -

Influence of body weight on the performance of glomerular filtration rate estimators in subjects with type 2 diabetes

Abstract

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