Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells

Tianruo Guo; David Tsai; John W. Morley; Gregg J. Suaning; Nigel H. Lovell; Socrates Dokos

doi:10.1109/EMBC.2013.6610560

Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells

Tianruo Guo, David Tsai, John W. Morley, Gregg J. Suaning, Nigel H. Lovell, Socrates Dokos

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

8 Citations (Scopus)

Abstract

![CDATA[We developed anatomically and biophysically detailed ionic models to understand how cell morphology contributes to the unique firing patterns of ON and OFF retinal ganglion cells (RGCs). With identical voltage-gated channel kinetics and distribution, cell morphology alone is sufficient to generate quantitatively distinct electrophysiological responses. Notably, recent experimental observations from ON and OFF RGCs can be closely reproduced by the variations in their cell morphologies alone. Our results suggest that RGC morphology in conjunction with biophysical properties and network connectivity are able to produce the diverse response repertoire of RGCs.]]

Original language	English
Title of host publication	Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan
Publisher	IEEE
Pages	4553-4556
Number of pages	4
ISBN (Print)	9781457702167
DOIs	https://doi.org/10.1109/EMBC.2013.6610560
Publication status	Published - 2013
Event	IEEE Engineering in Medicine and Biology Society. Conference - Duration: 3 Jul 2013 → …

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Name
ISSN (Print)	1557-170X

Conference

Conference	IEEE Engineering in Medicine and Biology Society. Conference
Period	3/07/13 → …

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10.1109/EMBC.2013.6610560

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Guo, T., Tsai, D., Morley, J. W., Suaning, G. J., Lovell, N. H., & Dokos, S. (2013). Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells. In Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan (pp. 4553-4556). IEEE. https://doi.org/10.1109/EMBC.2013.6610560

@inproceedings{6b86ff3ba1b9426f9ca23a5bf21cde6c,

title = "Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells",

abstract = "![CDATA[We developed anatomically and biophysically detailed ionic models to understand how cell morphology contributes to the unique firing patterns of ON and OFF retinal ganglion cells (RGCs). With identical voltage-gated channel kinetics and distribution, cell morphology alone is sufficient to generate quantitatively distinct electrophysiological responses. Notably, recent experimental observations from ON and OFF RGCs can be closely reproduced by the variations in their cell morphologies alone. Our results suggest that RGC morphology in conjunction with biophysical properties and network connectivity are able to produce the diverse response repertoire of RGCs.]]",

author = "Tianruo Guo and David Tsai and Morley, {John W.} and Suaning, {Gregg J.} and Lovell, {Nigel H.} and Socrates Dokos",

year = "2013",

doi = "10.1109/EMBC.2013.6610560",

language = "English",

isbn = "9781457702167",

publisher = "IEEE",

pages = "4553--4556",

booktitle = "Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan",

note = "IEEE Engineering in Medicine and Biology Society. Conference ; Conference date: 03-07-2013",

}

Guo, T, Tsai, D, Morley, JW, Suaning, GJ, Lovell, NH & Dokos, S 2013, Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells. in Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, pp. 4553-4556, IEEE Engineering in Medicine and Biology Society. Conference, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610560

Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells. / Guo, Tianruo; Tsai, David; Morley, John W. et al.
Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan. IEEE, 2013. p. 4553-4556.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

TY - GEN

T1 - Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells

AU - Guo, Tianruo

AU - Tsai, David

AU - Morley, John W.

AU - Suaning, Gregg J.

AU - Lovell, Nigel H.

AU - Dokos, Socrates

PY - 2013

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N2 - ![CDATA[We developed anatomically and biophysically detailed ionic models to understand how cell morphology contributes to the unique firing patterns of ON and OFF retinal ganglion cells (RGCs). With identical voltage-gated channel kinetics and distribution, cell morphology alone is sufficient to generate quantitatively distinct electrophysiological responses. Notably, recent experimental observations from ON and OFF RGCs can be closely reproduced by the variations in their cell morphologies alone. Our results suggest that RGC morphology in conjunction with biophysical properties and network connectivity are able to produce the diverse response repertoire of RGCs.]]

AB - ![CDATA[We developed anatomically and biophysically detailed ionic models to understand how cell morphology contributes to the unique firing patterns of ON and OFF retinal ganglion cells (RGCs). With identical voltage-gated channel kinetics and distribution, cell morphology alone is sufficient to generate quantitatively distinct electrophysiological responses. Notably, recent experimental observations from ON and OFF RGCs can be closely reproduced by the variations in their cell morphologies alone. Our results suggest that RGC morphology in conjunction with biophysical properties and network connectivity are able to produce the diverse response repertoire of RGCs.]]

UR - http://handle.uws.edu.au:8081/1959.7/541849

UR - http://embc2013.embs.org/

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DO - 10.1109/EMBC.2013.6610560

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BT - Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC '13), 3 - 7 July 2013, Osaka, Japan

PB - IEEE

T2 - IEEE Engineering in Medicine and Biology Society. Conference

Y2 - 3 July 2013

ER -

Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells

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