Abstract
We investigated if the magnitude of the Type 2 diabetes (T2D)-induced impairments in peak oxygen uptake (Vo2) and Vo2 kinetics was affected by menopausal status. Twenty-two women with T2D (8 premenopausal, 14 postmenopausal), and 22 nondiabetic (ND) women (11 premenopausal, 11 postmenopausal) matched by age (range = 30-59 yr) were recruited. Participants completed four bouts of constant-load cycling at 80% of their ventilatory threshold for the determination of Vo2kinetics. Cardiac output (CO) (inert gas rebreathing) was recorded at rest and at 30 s and 240 s during two additional bouts. Peak Vo2was significantly (P < 0.05) reduced in both groups with T2D compared with ND counterparts (premenopausal, 1.79 ± 0.16 vs. 1.55 ± 0.32 l/min; postmenopausal, 1.60 ± 0.30 vs. 1.45 ± 0.24 l/min). The time constant of phase II of the Vo2response was slowed (P < 0.05) in both groups with T2D compared with healthy counterparts (premenopausal, 29.1 ± 11.2 vs. 43.0 ± 12.2 s; postmenopausal, 33.0 ± 9.1 vs. 41.8 ± 17.7 s). At rest and during submaximal exercise absolute CO responses were lower, but the “gains” in CO larger (both P < 0.05) in both groups with T2D. Our results suggest that the magnitude of T2D-induced impairments in peak Vo2and Vo2kinetics is not affected by menopausal status in participants younger than 60 yr of age.
Original language | English |
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Pages (from-to) | R875-R883 |
Number of pages | 9 |
Journal | American Journal of Physiology |
Volume | 309 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- cycling
- exercise
- menopause
- non-insulin-dependent diabetes
- oxygen
- women