Inhibition of Histone H2B Gene Transcription and of Cellular Growth by a Truncated Viral trans-Activator Protein

C. L. Dent; J. K. Estridge; L. M. Kemp; D. S. Latchman

Inhibition of Histone H2B Gene Transcription and of Cellular Growth by a Truncated Viral trans-Activator Protein

C. L. Dent, J. K. Estridge, L. M. Kemp, D. S. Latchman

University College London

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.

Original language	English
Pages (from-to)	3258-3261
Number of pages	4
Journal	Molecular and Cellular Biology
Volume	10
Issue number	6
Publication status	Published - Jun 1990
Externally published	Yes

Cite this

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abstract = "The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.",

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AU - Dent, C. L.

AU - Estridge, J. K.

AU - Kemp, L. M.

AU - Latchman, D. S.

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AB - The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.

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Inhibition of Histone H2B Gene Transcription and of Cellular Growth by a Truncated Viral trans-Activator Protein

Abstract

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