Inter-individual variability in the improvement of physiological risk factors for disease : gene polymorphisms or simply regression to the mean?

In an informative and balanced review, Mori et al. (2009) explored the perplexing question of why people differ in their individual physiological responses to exercise training. We agree fully with Mori et al. (2009) that gene polymorphisms couldaccount for inter-individual differences in the exercise-modulated response of physiological risk factors of disease, and that a better understanding of associated issues should lead to more effective exercise prescription.