Interaction between mean arterial pressure and HbA1c in prediction of cardiovascular disease hospitalisation : a population-based case-control study

Dahai Yu, Zhanzheng Zhao, David Simmons

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14 Citations (Scopus)

Abstract

Objective. To explore the relationship between mean arterial pressure (MAP), HbA1c, and cardiovascular (CV) hospitalisation risk in type 2 diabetes. Design. Population-based case-control study. Settings. Primary and secondary care level in Cambridgeshire, United Kingdom. Participants. 588 patients with type 2 diabetes from 18 English general practices recording a CV hospitalisation in 2009–2011 were included. Risk-set sampling was used to select 2920 gender, age, and practice matched control type 2 diabetes patients. Main Outcome Measure. Conditional logistic regression was used to explore further dose-response relationships between MAP, HbA1c, and CV hospitalisation risk. Results. The relationship between MAP and CV hospitalisation was nonlinear (𝑃 < 0.001 for linearity test). The MAP associated with the lowest CV hospitalisation risk was 97 (95% CI: 93–101)mmHg. An interaction between MAP and HbA1c for increased risk of cardiovascular hospitalisation was observed among those with HbA1c < 7% (53mmol/mol) and MAP < 97mmHg. Conclusions. In type 2 diabetes, MAP is a good predictor of CV hospitalisation risk. CV hospitalisation is lowest with a MAP between 93 and 101mmHg. CV hospitalisation was particularly high among those with both a low MAP and a lower HbA1c.
Original languageEnglish
Article number8714745
Number of pages7
JournalJournal of Diabetes Research
Volume2016
DOIs
Publication statusPublished - 2016

Open Access - Access Right Statement

Copyright © 2016 Dahai Yu et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • diabetes
  • hospitals
  • medical care

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