Interactions between antidiabetic drugs and herbs : an overview of mechanisms of action and clinical implications

Ramesh C. Gupta; Dennis Chang; Srinivas Nammi; Alan Bensoussan; Kellie Bilinski; Basil D. Roufogalis

doi:10.1186/s13098-017-0254-9

Interactions between antidiabetic drugs and herbs : an overview of mechanisms of action and clinical implications

Ramesh C. Gupta, Dennis Chang, Srinivas Nammi, Alan Bensoussan, Kellie Bilinski, Basil D. Roufogalis

Western Sydney University

Research output: Contribution to journal › Article › peer-review

133 Citations (Scopus)

Abstract

Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb-drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb-drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb-drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

Original language	English
Article number	59
Number of pages	12
Journal	Diabetology and Metabolic Syndrome
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13098-017-0254-9
Publication status	Published - 2017

Open Access - Access Right Statement

© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Keywords

diabetes
drug synergism
drug-herb interactions
herbs
hypoglycemic agents
pharmacokinetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13098-017-0254-9

Cite this

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AU - Bensoussan, Alan

AU - Bilinski, Kellie

AU - Roufogalis, Basil D.

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N2 - Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb-drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb-drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb-drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

AB - Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb-drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb-drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb-drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

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ER -

Interactions between antidiabetic drugs and herbs : an overview of mechanisms of action and clinical implications

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

Access to Document

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