Interleukin-1 (IL-1) inhibitors : anakinra, rilonacept, and canakinumab

Kevin D. Pile; Garry G. Graham; Stephen M. Mahler

doi:10.1007/978-3-7643-8550-7_29

Interleukin-1 (IL-1) inhibitors : anakinra, rilonacept, and canakinumab

Kevin D. Pile
, Garry G. Graham
, Stephen M. Mahler

Research output: Chapter in Book / Conference Paper › Chapter

4 Citations (Scopus)

Abstract

Inhibitors of interleukin-1 (IL-1) are proteins which decrease the actions of the inflammatory cytokine, IL-1. There are two general mechanisms of IL-1 inhibitors: binding to the IL-1 receptor (anakinra) or binding directly to IL-1 (rilonacept and canakinumab). They are members of a general class termed biological disease-modifying antirheumatic drugs (bDMARDs). They are not classified as slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific and rapidly developing actions. Clinically, the major IL-1 inhibitor is anakinra.

Original language	English
Title of host publication	Compendium of Inflammatory Diseases
Editors	Michael J. Parnham
Place of Publication	Switzerland
Publisher	Springer
Pages	666-670
Number of pages	5
ISBN (Electronic)	9783764385507
ISBN (Print)	9783764385309
DOIs	https://doi.org/10.1007/978-3-7643-8550-7_29
Publication status	Published - 2016

Keywords

interleukin-1
antirheumatic agents

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10.1007/978-3-7643-8550-7_29

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abstract = "Inhibitors of interleukin-1 (IL-1) are proteins which decrease the actions of the inflammatory cytokine, IL-1. There are two general mechanisms of IL-1 inhibitors: binding to the IL-1 receptor (anakinra) or binding directly to IL-1 (rilonacept and canakinumab). They are members of a general class termed biological disease-modifying antirheumatic drugs (bDMARDs). They are not classified as slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific and rapidly developing actions. Clinically, the major IL-1 inhibitor is anakinra.",

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AU - Graham, Garry G.

AU - Mahler, Stephen M.

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Y1 - 2016

N2 - Inhibitors of interleukin-1 (IL-1) are proteins which decrease the actions of the inflammatory cytokine, IL-1. There are two general mechanisms of IL-1 inhibitors: binding to the IL-1 receptor (anakinra) or binding directly to IL-1 (rilonacept and canakinumab). They are members of a general class termed biological disease-modifying antirheumatic drugs (bDMARDs). They are not classified as slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific and rapidly developing actions. Clinically, the major IL-1 inhibitor is anakinra.

AB - Inhibitors of interleukin-1 (IL-1) are proteins which decrease the actions of the inflammatory cytokine, IL-1. There are two general mechanisms of IL-1 inhibitors: binding to the IL-1 receptor (anakinra) or binding directly to IL-1 (rilonacept and canakinumab). They are members of a general class termed biological disease-modifying antirheumatic drugs (bDMARDs). They are not classified as slow-acting antirheumatic drugs (SAARDs) because they are considered to have more specific and rapidly developing actions. Clinically, the major IL-1 inhibitor is anakinra.

KW - interleukin-1

KW - antirheumatic agents

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:40018

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M3 - Chapter

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EP - 670

BT - Compendium of Inflammatory Diseases

A2 - Parnham, Michael J.

PB - Springer

CY - Switzerland

ER -

Interleukin-1 (IL-1) inhibitors : anakinra, rilonacept, and canakinumab

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Keywords

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