TY - JOUR
T1 - Intracellular copper routing
T2 - The role of copper chaperones
AU - Harrison, Mark D.
AU - Jones, Christopher E.
AU - Solioz, Marc
AU - Dameron, Charles T.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Copper is required by all living systems. Cells have a variety of mechanisms to deal with this essential, yet toxic trace element. A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the 'copper chaperones'. They are a family of conserved proteins present in prokaryotes and eukaryotes, which suggests that copper chaperones are used throughout nature for intracellular copper routing. Copyright (C) 2000 Elsevier Science Ltd.
AB - Copper is required by all living systems. Cells have a variety of mechanisms to deal with this essential, yet toxic trace element. A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the 'copper chaperones'. They are a family of conserved proteins present in prokaryotes and eukaryotes, which suggests that copper chaperones are used throughout nature for intracellular copper routing. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0002974033&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(99)01492-9
DO - 10.1016/S0968-0004(99)01492-9
M3 - Review article
C2 - 10637610
AN - SCOPUS:0002974033
SN - 0968-0004
VL - 25
SP - 29
EP - 32
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -