Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands

Benjamin J. Pages; Jennette Sakoff; Jayne Gilbert; Yingjie Zhang; Feng Li; Dan Preston; James D. Crowley; Janice R. Aldrich-Wright

doi:10.1016/j.jinorgbio.2016.06.017

Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands

Benjamin J. Pages
, Jennette Sakoff
, Jayne Gilbert
, Yingjie Zhang
, Feng Li
, Dan Preston
, James D. Crowley
, Janice R. Aldrich-Wright

Nanoscale Org & Dynam Grp
Calvary Mater Newcastle Hospital
Australian Nuclear Science and Technology Organisation
University of Otago

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PL is a bidentate pyridyl-1,2,3-triazole "click" ligand and AL is the R,R or S,S isomer of 1,2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.

Original language	English
Pages (from-to)	92-99
Number of pages	8
Journal	Journal of Inorganic Biochemistry
Volume	165
DOIs	https://doi.org/10.1016/j.jinorgbio.2016.06.017
Publication status	Published - 2016
Event	1st International Symposium on Clinical and Experimental Metallodrugs in Medicine - Cancer Chemotherapy (CEMM) - Honolulu Duration: 1 Dec 2015 → …

Keywords

Cell growth inhibition
Click
Platinum
Triazole
X-ray crystal structure

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10.1016/j.jinorgbio.2016.06.017

Cite this

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title = "Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands",

abstract = "Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PL is a bidentate pyridyl-1,2,3-triazole {"}click{"} ligand and AL is the R,R or S,S isomer of 1,2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.",

keywords = "Cell growth inhibition, Click, Platinum, Triazole, X-ray crystal structure",

author = "Pages, \{Benjamin J.\} and Jennette Sakoff and Jayne Gilbert and Yingjie Zhang and Feng Li and Dan Preston and Crowley, \{James D.\} and Aldrich-Wright, \{Janice R.\}",

year = "2016",

doi = "10.1016/j.jinorgbio.2016.06.017",

language = "English",

volume = "165",

pages = "92--99",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

note = "1st International Symposium on Clinical and Experimental Metallodrugs in Medicine - Cancer Chemotherapy (CEMM) ; Conference date: 01-12-2015",

}

TY - JOUR

T1 - Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands

AU - Pages, Benjamin J.

AU - Sakoff, Jennette

AU - Gilbert, Jayne

AU - Zhang, Yingjie

AU - Li, Feng

AU - Preston, Dan

AU - Crowley, James D.

AU - Aldrich-Wright, Janice R.

PY - 2016

Y1 - 2016

N2 - Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PL is a bidentate pyridyl-1,2,3-triazole "click" ligand and AL is the R,R or S,S isomer of 1,2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.

AB - Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PL is a bidentate pyridyl-1,2,3-triazole "click" ligand and AL is the R,R or S,S isomer of 1,2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.

KW - Cell growth inhibition

KW - Click

KW - Platinum

KW - Triazole

KW - X-ray crystal structure

UR - http://handle.uws.edu.au:8081/1959.7/uws:35733

U2 - 10.1016/j.jinorgbio.2016.06.017

DO - 10.1016/j.jinorgbio.2016.06.017

M3 - Article

C2 - 27389828

SN - 0162-0134

VL - 165

SP - 92

EP - 99

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

T2 - 1st International Symposium on Clinical and Experimental Metallodrugs in Medicine - Cancer Chemotherapy (CEMM)

Y2 - 1 December 2015

ER -

Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole 'click' ligands

Abstract

Keywords

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