Abstract
Aim: To investigate the hippocampal neuronal injury induced by β-amyloid peptide (Aβ) in rats and the candidate contribution of JNK signal transduction pathway to Aβ toxicity. Methods: Rats were bilaterally injected with Aβ 1-40 into hippocampi CA1 area. The pathological changes, survival and apoptosis, and ultrastructure of hippocampal neurons, as well as p-JNK positive cells were observed by HE staining, Nissl staining, TUNEL staining, immunohistochemistry and transmission electron microscopy, respectively. Results: The pyramidal cells in hippocampus arranged loosely with decreased cell number. The gliacytes significantly proliferated. Significant apoptotic features were observed in CA1 ultrastructure. TUNEL-positive cells and p-JNK-positive cells significantly increased (P < 0.01). Conclusions: Aβ can significantly induce neuronal apoptosis in hippocampus in rats. JNK signal transduction pathway participates Aβ neuronal toxicity of apoptotic injury.
| Translated title of the contribution | JNK signaling pathway is involved in the damage of Aβ-induced hippocampal neurons in rats |
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| Original language | Chinese (Simplified) |
| Pages (from-to) | 1034-1037 |
| Number of pages | 4 |
| Journal | Chinese Pharmacological Bulletin |
| Volume | 26 |
| Issue number | 8 |
| Publication status | Published - 2010 |