TY - GEN
T1 - Joint symbolic dynamics as a model-free approach to study interdependence in cardio-respiratory time series
AU - Baumert, Mathias
AU - Brown, Rachael
AU - Duma, Stephen
AU - Broe, G. Anthony
AU - Kabir, Muammar M.
AU - Macefield, Vaughan G.
PY - 2012
Y1 - 2012
N2 - Heart rate and respiration display fluctuations that are interlinked by central regulatory mechanisms of the autonomic nervous system (ANS). Joint assessment of respiratory time series along with heart rate variability (HRV) may therefore provide information on ANS dysfunction. The aim of this study was to investigate cardio-respiratory LQWHUDFWLRQ_ LQ_ SDWLHQWV_ ZLWK_ 3DUNLQVRQ¶V_ GLVHDVH (PD), a neurodegenerative disorder that is associated with progressive ANS dysfunction. Short-term ECG and respiration were recorded in 25 PD patients and 28 healthy controls during rest. To assess ANS dysfunction we analyzed joint symbolic dynamics of heart rate and respiration, cardio-respiratory synchrograms along with heart rate variability. Neither HRV nor cardio-respiratory synchrograms were significantly altered in PD patients. Symbolic analysis, however, identified a significant reduction in cardio-respiratory interactions in PD patients compared to healthy controls (16 ± 3.6 % vs. 20 ± 6.1 %; p = 0.02). In conclusion, joint symbolic analysis of cardiorespiratory dynamics provides a powerful tool to detect early signs of autonomic nervous system dysfunction in 3DUNLQVRQ¶V_ disease patients at an early stage of the disease.
AB - Heart rate and respiration display fluctuations that are interlinked by central regulatory mechanisms of the autonomic nervous system (ANS). Joint assessment of respiratory time series along with heart rate variability (HRV) may therefore provide information on ANS dysfunction. The aim of this study was to investigate cardio-respiratory LQWHUDFWLRQ_ LQ_ SDWLHQWV_ ZLWK_ 3DUNLQVRQ¶V_ GLVHDVH (PD), a neurodegenerative disorder that is associated with progressive ANS dysfunction. Short-term ECG and respiration were recorded in 25 PD patients and 28 healthy controls during rest. To assess ANS dysfunction we analyzed joint symbolic dynamics of heart rate and respiration, cardio-respiratory synchrograms along with heart rate variability. Neither HRV nor cardio-respiratory synchrograms were significantly altered in PD patients. Symbolic analysis, however, identified a significant reduction in cardio-respiratory interactions in PD patients compared to healthy controls (16 ± 3.6 % vs. 20 ± 6.1 %; p = 0.02). In conclusion, joint symbolic analysis of cardiorespiratory dynamics provides a powerful tool to detect early signs of autonomic nervous system dysfunction in 3DUNLQVRQ¶V_ disease patients at an early stage of the disease.
KW - Parkinson's disease
KW - autonomic nervous system
KW - electrocardiography
KW - heart rate monitoring
KW - time-series analysis
UR - http://handle.uws.edu.au:8081/1959.7/524071
UR - https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=14633
U2 - 10.1109/EMBC.2012.6346765
DO - 10.1109/EMBC.2012.6346765
M3 - Conference Paper
SN - 9781424441204
SP - 3680
EP - 3683
BT - Proceedings of the 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): 28 Aug. 2012 - 1 Sep. 2012, San Diego, California
PB - IEEE
T2 - IEEE Engineering in Medicine and Biology Society. Conference
Y2 - 28 August 2012
ER -