TY - JOUR
T1 - Large-pore periodic mesoporous organosilicas as advanced bactericide platforms
AU - Birault, A.
AU - Molina, E.
AU - Toquer, G.
AU - Lacroix-Desmazes, P.
AU - Marcotte, N.
AU - Carcel, C.
AU - Katouli, M.
AU - Bartlett, John R.
AU - Gerardin, C.
AU - Wong Chi Man, M.
PY - 2018
Y1 - 2018
N2 - Despite the versatility of periodic mesoporous organosilicas (PMOs), the bactericide capacity of these hybrid platforms has seldom been explored. Herein, we describe the synthesis of large-pore phenylene-bridged PMOs, mesostructured by polyion complex (PIC) micelles (PICPMOs) incorporating an antibiotic, neomycin B. A key feature of this approach is that the bioactive molecules are directly encapsulated within the PICPMOs during their formation. The engineered PICPMOs exhibit a well-ordered hexagonal mesophase with a molecular-scale crystallinity and large mesopores (8 nm), which facilitates pH-triggered delivery of the drug. The results obtained with a pathogenic Escherichia coli strain clearly demonstrate the potential of such PICPMOs for antibacterial applications.
AB - Despite the versatility of periodic mesoporous organosilicas (PMOs), the bactericide capacity of these hybrid platforms has seldom been explored. Herein, we describe the synthesis of large-pore phenylene-bridged PMOs, mesostructured by polyion complex (PIC) micelles (PICPMOs) incorporating an antibiotic, neomycin B. A key feature of this approach is that the bioactive molecules are directly encapsulated within the PICPMOs during their formation. The engineered PICPMOs exhibit a well-ordered hexagonal mesophase with a molecular-scale crystallinity and large mesopores (8 nm), which facilitates pH-triggered delivery of the drug. The results obtained with a pathogenic Escherichia coli strain clearly demonstrate the potential of such PICPMOs for antibacterial applications.
UR - https://hdl.handle.net/1959.7/uws:78005
U2 - 10.1021/acsabm.8b00474
DO - 10.1021/acsabm.8b00474
M3 - Article
SN - 2576-6422
VL - 1
SP - 1787
EP - 1792
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 6
ER -