TY - JOUR
T1 - Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas
AU - Duan, Chang-Ling
AU - Jiang, Yu
AU - Jiang, Yong
AU - Lin, Cheng-Ren
AU - Liu, Jian-Xun
AU - Tu, Peng-Fei
PY - 2009
Y1 - 2009
N2 - We investigated the chemical constituents of the fibrous root of Ophiopogon japonicus and their cytotoxicities against Hela and Hep2 cells. Ten compounds were purified by various chromatographic techniques. Their structures were identified as 2'hydroxylophiopogonone A (1), 5,8-dimethoxy-6-methyl-7-hydroxy-3-(2'hydroxy-4'-methoxybenzyl) chroman-4-one (2), 5,7dihydroxy-6,8-dimethyl-3- (4'hydroxybenzyl) chroman-4-one (3), 7,4'dihydroxy--5methoxyflavanone (4), N-trans-coumaroyltyramine (5), N-trans-coumaroyloctopamine (6), N-trans-feruloyltyramine (7), 4-hydroxycinnamic acid (8), caffeic acid (9), and ferulic acid (10) on the basis of spectroscopic analyses. Compounds 4, 6, 7, 9, 10 were obtained from this genus for the first time. The cytotoxic activities of 1, 2, 4, 5, 6, 7, 9 and 10 against Hela and Hep2 cells are described.
AB - We investigated the chemical constituents of the fibrous root of Ophiopogon japonicus and their cytotoxicities against Hela and Hep2 cells. Ten compounds were purified by various chromatographic techniques. Their structures were identified as 2'hydroxylophiopogonone A (1), 5,8-dimethoxy-6-methyl-7-hydroxy-3-(2'hydroxy-4'-methoxybenzyl) chroman-4-one (2), 5,7dihydroxy-6,8-dimethyl-3- (4'hydroxybenzyl) chroman-4-one (3), 7,4'dihydroxy--5methoxyflavanone (4), N-trans-coumaroyltyramine (5), N-trans-coumaroyloctopamine (6), N-trans-feruloyltyramine (7), 4-hydroxycinnamic acid (8), caffeic acid (9), and ferulic acid (10) on the basis of spectroscopic analyses. Compounds 4, 6, 7, 9, 10 were obtained from this genus for the first time. The cytotoxic activities of 1, 2, 4, 5, 6, 7, 9 and 10 against Hela and Hep2 cells are described.
UR - http://handle.uws.edu.au:8081/1959.7/541077
M3 - Article
SN - 1003-1057
VL - 18
SP - 236
EP - 239
JO - Journal of Chinese Pharmaceutical Sciences
JF - Journal of Chinese Pharmaceutical Sciences
IS - 3
ER -