Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas

Chang-Ling Duan, Yu Jiang, Yong Jiang, Cheng-Ren Lin, Jian-Xun Liu, Peng-Fei Tu

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We investigated the chemical constituents of the fibrous root of Ophiopogon japonicus and their cytotoxicities against Hela and Hep2 cells. Ten compounds were purified by various chromatographic techniques. Their structures were identified as 2'hydroxylophiopogonone A (1), 5,8-dimethoxy-6-methyl-7-hydroxy-3-(2'hydroxy-4'-methoxybenzyl) chroman-4-one (2), 5,7dihydroxy-6,8-dimethyl-3- (4'hydroxybenzyl) chroman-4-one (3), 7,4'dihydroxy--5methoxyflavanone (4), N-trans-coumaroyltyramine (5), N-trans-coumaroyloctopamine (6), N-trans-feruloyltyramine (7), 4-hydroxycinnamic acid (8), caffeic acid (9), and ferulic acid (10) on the basis of spectroscopic analyses. Compounds 4, 6, 7, 9, 10 were obtained from this genus for the first time. The cytotoxic activities of 1, 2, 4, 5, 6, 7, 9 and 10 against Hela and Hep2 cells are described.
    Original languageEnglish
    Pages (from-to)236-239
    Number of pages4
    JournalJournal of Chinese Pharmaceutical Sciences
    Volume18
    Issue number3
    Publication statusPublished - 2009

    Fingerprint

    Dive into the research topics of 'Liposoluble chemical constituents from the fibrous root of Ophiopogon japonicas'. Together they form a unique fingerprint.

    Cite this