Long COVID and post-infective fatigue syndrome : a review

Carolina X. Sandler; Vegard B. B. Wyller; Rona Moss-Morris; Dedra Buchwald; Esther Crawley; Jeannine Hautvast; Ben Z. Katz; Hans Knoop; Paul Little; Renee Taylor; Knut-Arne Wensaas; Andrew R. Lloyd

doi:10.1093/ofid/ofab440

Long COVID and post-infective fatigue syndrome : a review

Carolina X. Sandler
, Vegard B. B. Wyller
, Rona Moss-Morris
, Dedra Buchwald
, Esther Crawley
, Jeannine Hautvast
, Ben Z. Katz
, Hans Knoop
, Paul Little
, Renee Taylor
, Knut-Arne Wensaas
, Andrew R. Lloyd

Research output: Contribution to journal › Article › peer-review

191 Citations (Scopus)

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Abstract

Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.

Original language	English
Article number	ofab440
Number of pages	7
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofab440
Publication status	Published - 1 Oct 2021

Bibliographical note

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© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/ licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected] https://doi.org/10.1093/ofid/ofab440

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title = "Long COVID and post-infective fatigue syndrome : a review",

abstract = "Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed {"}long-COVID{"}), with up to 46\% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13\% to 33\% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10\%-35\% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.",

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AU - Wyller, Vegard B. B.

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AU - Crawley, Esther

AU - Hautvast, Jeannine

AU - Katz, Ben Z.

AU - Knoop, Hans

AU - Little, Paul

AU - Taylor, Renee

AU - Wensaas, Knut-Arne

AU - Lloyd, Andrew R.

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N2 - Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.

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Long COVID and post-infective fatigue syndrome : a review

Abstract

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