Long term recovery of median nerve repair using laser-activated chitosan adhesive films

Matthew J. Barton, John W. Morley, Marcus A. Stoodley, Sumaiya Shaikh, David A. Mahns, Antonio Lauto

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Sutures remain the standard peripheral nerve repair technique, whether applied directly or indirectly to nerve tissue. Unfortunately, significant postoperative complications can result, such as inflammation, neuroma formation and foreign body reactions. Photochemical-tissue-bonding (PTB) using rose Bengal (RB) integrated into a chitosan bioadhesive is an alternative nerve repair device that removes the need for sutures. Rats were arranged into three groups: RB-chitosan adhesives-repair, end-to-end epineural suture-repair (surgical standard) and sham laser-irradiated control. Groups were compared through histological assessment, electrophysiological recordings and grip motor strength. RB-chitosan adhesive repaired nerves displayed comparable results when compared to the standard suture-repair based on histological and electrophysiological findings. Functionally, RB-chitosan adhesive was associated with a quicker and more pronounced recovery of grip force when compared to the suture-repair.
    Original languageEnglish
    Pages (from-to)196-207
    Number of pages12
    JournalJournal of Biophotonics
    Volume8
    Issue number3
    DOIs
    Publication statusPublished - 2015

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