Long-term results following an anatomically-based surgical technique for resection of colon cancer : a comparison with results from complete mesocolic excision

Les Bokey, Pierre H. Chapuis, Charles Chan, Peter Stewart, Matthew J. F. X. Rickard, Anil Keshava, Owen F. Dent

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Aim. Complete mesocolic excision (CME) has been advocated as likely to improve the long-term oncological outcome from resection of colon cancer, although there is a paucity of long-term results in the literature. The aim of this study was to supplement our previously published results from resection of colon cancer based on a standardized technique of precise dissection along anatomical planes with high vascular ligation and to compare our long-term results with those of recent European studies of CME. Method. Data were drawn from a prospective hospital registry of consecutive resections for colonic cancer between 1996 and 2007 inclusive with follow-up to the end of 2012. The principle outcomes from potentially curative resections were 5-year Kaplan-Meier rates of local recurrence, systemic recurrence, overall survival and cancer-specific survival. Secondary outcomes for all resections were postoperative complications, number of lymph nodes retrieved and R0 status. Results. For 779 potentially curative resections the local recurrence rate was 2.1% (95% CI 1.3-3.4), the systemic recurrence rate was 10.2% (CI 8.1-12.7), the 5-year overall survival rate was 76.2% (CI 73.0-79.0), the cancer-specific rate was 89.8% (CI 87.3-91.9). For all 905 resections, rates of 14 surgical complications were low and not dissimilar to a comparable study. The median lymph node count was 15, range 0-113. R0 status was confirmed in 883/905 patients (97.6%, CI 96.4-98.5). Conclusion. For colon cancer, meticulous dissection along anatomical planes together with high vascular ligation results in few complications, a high R0 rate, low recurrence and high survival.
Original languageEnglish
Pages (from-to)676-683
Number of pages8
JournalColorectal Disease
Volume18
Issue number7
DOIs
Publication statusPublished - 2016

Keywords

  • cancer
  • colon (anatomy)
  • complications
  • rectum
  • surgery

Fingerprint

Dive into the research topics of 'Long-term results following an anatomically-based surgical technique for resection of colon cancer : a comparison with results from complete mesocolic excision'. Together they form a unique fingerprint.

Cite this