Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A Challenging Case

Natthawadee Laokulrath; Esther Chuwa; Mihir Gudi; Puay Hoon Tan

doi:10.1159/000540029

Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A Challenging Case

Natthawadee Laokulrath
, Esther Chuwa
, Mihir Gudi
, Puay Hoon Tan

Mahidol University
KK Women's and Children's Hospital
Solis Breast Care and Surgery Centre
Luma Medical Centre
Parkway Laboratory Services Ltd

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions. Case Presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells). Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.

Original language	English
Pages (from-to)	455-462
Number of pages	8
Journal	Pathobiology
Volume	91
Issue number	6
DOIs	https://doi.org/10.1159/000540029
Publication status	Published - 1 Dec 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 S. Karger AG, Basel.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Core biopsy
ER positivity
Frozen section
Low-grade adenosquamous carcinoma

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10.1159/000540029

Cite this

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title = "Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A Challenging Case",

abstract = "Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions. Case Presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40\% of tumour cells). Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.",

keywords = "Breast cancer, Core biopsy, ER positivity, Frozen section, Low-grade adenosquamous carcinoma",

author = "Natthawadee Laokulrath and Esther Chuwa and Mihir Gudi and Tan, \{Puay Hoon\}",

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doi = "10.1159/000540029",

language = "English",

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T1 - Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy

T2 - A Challenging Case

AU - Laokulrath, Natthawadee

AU - Chuwa, Esther

AU - Gudi, Mihir

AU - Tan, Puay Hoon

PY - 2024/12/1

Y1 - 2024/12/1

N2 - Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions. Case Presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells). Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.

AB - Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions. Case Presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells). Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.

KW - Breast cancer

KW - Core biopsy

KW - ER positivity

KW - Frozen section

KW - Low-grade adenosquamous carcinoma

UR - https://www.scopus.com/pages/publications/85211447937

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AN - SCOPUS:85211447937

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VL - 91

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JO - Pathobiology

JF - Pathobiology

IS - 6

ER -

Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A Challenging Case

Abstract

Bibliographical note

UN SDGs

Keywords

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