LOX-1-mediated effects on vascular cells in atherosclerosis

Dimitry A. Chistiakov; Alexander N. Orekhov; Yuri V. Bobryshev

doi:10.1159/000443123

LOX-1-mediated effects on vascular cells in atherosclerosis

Dimitry A. Chistiakov, Alexander N. Orekhov, Yuri V. Bobryshev

Western Sydney University

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly upregulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result inendothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima,formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells(VSMCs), as well as in plaque destabilization and rupture. In this review, we consider effects ofthe LOX-1/oxLDL axis on several types of vascular cells such as ECs, VSMCs, and macrophages.

Original language	English
Pages (from-to)	1851-1859
Number of pages	9
Journal	Cellular Physiology and Biochemistry
Volume	38
Issue number	5
DOIs	https://doi.org/10.1159/000443123
Publication status	Published - 2016

Open Access - Access Right Statement

© 2016 The Author(s) Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND)(http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. The final, published version of this article is available at https://www.karger.com/?doi=10.1159/000443123

Keywords

arteries
atherogenesis
atherosclerosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000443123

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Cite this

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title = "LOX-1-mediated effects on vascular cells in atherosclerosis",

abstract = "In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly upregulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result inendothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima,formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells(VSMCs), as well as in plaque destabilization and rupture. In this review, we consider effects ofthe LOX-1/oxLDL axis on several types of vascular cells such as ECs, VSMCs, and macrophages.",

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AU - Chistiakov, Dimitry A.

AU - Orekhov, Alexander N.

AU - Bobryshev, Yuri V.

PY - 2016

Y1 - 2016

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AB - In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly upregulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result inendothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima,formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells(VSMCs), as well as in plaque destabilization and rupture. In this review, we consider effects ofthe LOX-1/oxLDL axis on several types of vascular cells such as ECs, VSMCs, and macrophages.

KW - arteries

KW - atherogenesis

KW - atherosclerosis

UR - http://handle.uws.edu.au:8081/1959.7/uws:35552

U2 - 10.1159/000443123

DO - 10.1159/000443123

M3 - Article

SN - 1015-8987

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EP - 1859

JO - Cellular Physiology and Biochemistry

JF - Cellular Physiology and Biochemistry

IS - 5

ER -

LOX-1-mediated effects on vascular cells in atherosclerosis

Abstract

Open Access - Access Right Statement

Keywords

UN SDGs

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