TY - JOUR
T1 - LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients
AU - Chan, Daniel Kam Yin
AU - Ng, Ping Wing
AU - Mok, Vincent
AU - Yeung, Jonas
AU - Fang, Zhi Ming
AU - Clarke, Raymond
AU - Leung, Edward
AU - Wong, Lawrence
PY - 2008
Y1 - 2008
N2 - The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age˃50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
AB - The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age˃50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
UR - http://handle.uws.edu.au:8081/1959.7/532711
U2 - 10.1007/s00702-008-0065-0
DO - 10.1007/s00702-008-0065-0
M3 - Article
SN - 0300-9564
VL - 115
SP - 1275
EP - 1277
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 9
ER -