Macrophage-stimulating activity of polysaccharides extracted from fruiting bodies of Coriolus versicolor (Turkey tail mushroom)

Sang-Chul Jeong, Byung-Keun Yang, Guknam Kim, Hun Jeong, Michael A. Wilson, Yip Cho, Koyyalamudi Sunder Rao, Chi-Hyun Song

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    Abstract

    The macrophage-stimulating effect of polysaccharides extracted from Coriolus versicolor (Turkey Tail mushroom) was investigated, and their effectiveness was compared with that of lipopolysaccharide (LPS). The purified polysaccharide (CV-S2-Fr.I) of C. versicolor obtained by Sepharose CL-6B gel chromatography stimulated macrophage lysosomal enzyme activity by 250% at a concentration of 100 µg/mL, which was higher than that of LPS at the same concentration. When CV-S2-Fr.I was used in combination with interferon-γ, there was a marked cooperative induction of nitric oxide production. However, CV-S2-Fr.I had no effect on nitric oxide production by itself. The proportion of C3-positive macrophages in the CV-S2-Fr.I group increased by 7.2-fold compared with the control group.
    Original languageEnglish
    Pages (from-to)175-181
    JournalJournal of Medicinal Food
    Volume9
    Issue number2
    Publication statusPublished - 2006

    Keywords

    • Coriolus versicolor
    • macrophage-stimulating activity
    • polysaccharide

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