Abstract
The macrophage-stimulating effect of polysaccharides extracted from Coriolus versicolor (Turkey Tail mushroom) was investigated, and their effectiveness was compared with that of lipopolysaccharide (LPS). The purified polysaccharide (CV-S2-Fr.I) of C. versicolor obtained by Sepharose CL-6B gel chromatography stimulated macrophage lysosomal enzyme activity by 250% at a concentration of 100 µg/mL, which was higher than that of LPS at the same concentration. When CV-S2-Fr.I was used in combination with interferon-γ, there was a marked cooperative induction of nitric oxide production. However, CV-S2-Fr.I had no effect on nitric oxide production by itself. The proportion of C3-positive macrophages in the CV-S2-Fr.I group increased by 7.2-fold compared with the control group.
Original language | English |
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Pages (from-to) | 175-181 |
Journal | Journal of Medicinal Food |
Volume | 9 |
Issue number | 2 |
Publication status | Published - 2006 |
Keywords
- Coriolus versicolor
- macrophage-stimulating activity
- polysaccharide