Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

Harikrishnan Balachandran; Chansavath Phetsouphanh; David Agapiou; Anurag Adhikari; Chaturaka Rodrigo; Mohamed Hammoud; Lok Bahadur Shrestha; Elizabeth Keoshkerian; Money Gupta; Stuart Turville; Daniel Christ; Cecile King; Sarah C. Sasson; Adam Bartlett; Branka Grubor-Bauk; William Rawlinson; Anupriya Aggarwal; Alberto Ospina Stella; Vera Klemm; Michael M. Mina; Jeffrey J. Post; Bernard Hudson; Nicky Gilroy; Pam Konecny; Golo Ahlenstiel; Dominic E. Dwyer; Tania C. Sorrell; Anthony Kelleher; Nicodemus Tedla; Andrew R. Lloyd; Marianne Martinello; Rowena A. Bull; null COSIN Study Group

doi:10.1016/j.celrep.2022.110345

Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

Harikrishnan Balachandran, Chansavath Phetsouphanh, David Agapiou, Anurag Adhikari, Chaturaka Rodrigo, Mohamed Hammoud, Lok Bahadur Shrestha, Elizabeth Keoshkerian, Money Gupta, Stuart Turville, Daniel Christ, Cecile King, Sarah C. Sasson, Adam Bartlett, Branka Grubor-Bauk, William Rawlinson, Anupriya Aggarwal, Alberto Ospina Stella, Vera Klemm, Michael M. MinaJeffrey J. Post, Bernard Hudson, Nicky Gilroy, Pam Konecny, Golo Ahlenstiel, Dominic E. Dwyer, Tania C. Sorrell, Anthony Kelleher, Nicodemus Tedla, Andrew R. Lloyd, Marianne Martinello, Rowena A. Bull, COSIN Study Group

Western Sydney University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.

Original language	English
Article number	110345
Number of pages	18
Journal	Cell Reports
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2022.110345
Publication status	Published - 2022

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10.1016/j.celrep.2022.110345

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Balachandran, H., Phetsouphanh, C., Agapiou, D., Adhikari, A., Rodrigo, C., Hammoud, M., Shrestha, L. B., Keoshkerian, E., Gupta, M., Turville, S., Christ, D., King, C., Sasson, S. C., Bartlett, A., Grubor-Bauk, B., Rawlinson, W., Aggarwal, A., Stella, A. O., Klemm, V., ... COSIN Study Group (2022). Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses. Cell Reports, 38(6), Article 110345. https://doi.org/10.1016/j.celrep.2022.110345

@article{ca49c2d2bd5c4af0a693db030a525796,

title = "Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses",

abstract = "Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.",

author = "Harikrishnan Balachandran and Chansavath Phetsouphanh and David Agapiou and Anurag Adhikari and Chaturaka Rodrigo and Mohamed Hammoud and Shrestha, {Lok Bahadur} and Elizabeth Keoshkerian and Money Gupta and Stuart Turville and Daniel Christ and Cecile King and Sasson, {Sarah C.} and Adam Bartlett and Branka Grubor-Bauk and William Rawlinson and Anupriya Aggarwal and Stella, {Alberto Ospina} and Vera Klemm and Mina, {Michael M.} and Post, {Jeffrey J.} and Bernard Hudson and Nicky Gilroy and Pam Konecny and Golo Ahlenstiel and Dwyer, {Dominic E.} and Sorrell, {Tania C.} and Anthony Kelleher and Nicodemus Tedla and Lloyd, {Andrew R.} and Marianne Martinello and Bull, {Rowena A.} and {COSIN Study Group}",

year = "2022",

doi = "10.1016/j.celrep.2022.110345",

language = "English",

volume = "38",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "6",

}

Balachandran, H, Phetsouphanh, C, Agapiou, D, Adhikari, A, Rodrigo, C, Hammoud, M, Shrestha, LB, Keoshkerian, E, Gupta, M, Turville, S, Christ, D, King, C, Sasson, SC, Bartlett, A, Grubor-Bauk, B, Rawlinson, W, Aggarwal, A, Stella, AO, Klemm, V, Mina, MM, Post, JJ, Hudson, B, Gilroy, N, Konecny, P, Ahlenstiel, G, Dwyer, DE, Sorrell, TC, Kelleher, A, Tedla, N, Lloyd, AR, Martinello, M, Bull, RA & COSIN Study Group 2022, 'Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses', Cell Reports, vol. 38, no. 6, 110345. https://doi.org/10.1016/j.celrep.2022.110345

TY - JOUR

T1 - Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

AU - Balachandran, Harikrishnan

AU - Phetsouphanh, Chansavath

AU - Agapiou, David

AU - Adhikari, Anurag

AU - Rodrigo, Chaturaka

AU - Hammoud, Mohamed

AU - Shrestha, Lok Bahadur

AU - Keoshkerian, Elizabeth

AU - Gupta, Money

AU - Turville, Stuart

AU - Christ, Daniel

AU - King, Cecile

AU - Sasson, Sarah C.

AU - Bartlett, Adam

AU - Grubor-Bauk, Branka

AU - Rawlinson, William

AU - Aggarwal, Anupriya

AU - Stella, Alberto Ospina

AU - Klemm, Vera

AU - Mina, Michael M.

AU - Post, Jeffrey J.

AU - Hudson, Bernard

AU - Gilroy, Nicky

AU - Konecny, Pam

AU - Ahlenstiel, Golo

AU - Dwyer, Dominic E.

AU - Sorrell, Tania C.

AU - Kelleher, Anthony

AU - Tedla, Nicodemus

AU - Lloyd, Andrew R.

AU - Martinello, Marianne

AU - Bull, Rowena A.

AU - COSIN Study Group, null

PY - 2022

Y1 - 2022

N2 - Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.

AB - Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.

UR - https://hdl.handle.net/1959.7/uws:76371

U2 - 10.1016/j.celrep.2022.110345

DO - 10.1016/j.celrep.2022.110345

M3 - Article

SN - 2211-1247

VL - 38

JO - Cell Reports

JF - Cell Reports

IS - 6

M1 - 110345

ER -

Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses

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