Abstract
The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
| Original language | English |
|---|---|
| Pages (from-to) | 415-419 |
| Number of pages | 5 |
| Journal | Nature |
| Volume | 589 |
| Issue number | 7842 |
| DOIs | |
| Publication status | Published - 21 Jan 2021 |
Bibliographical note
Publisher Copyright:© 2020, The Author(s).
Keywords
- health surveys
- measles
- vaccination
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In: Nature, Vol. 589, No. 7842, 21.01.2021, p. 415-419.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Mapping routine measles vaccination in low- and middle-income countries
AU - Sbarra, Alyssa N.
AU - Rolfe, Sam
AU - Nguyen, Jason Q.
AU - Earl, Lucas
AU - Galles, Natalie C.
AU - Marks, Ashley
AU - Abbas, Kaja M.
AU - Abbasi-Kangevari, Mohsen
AU - Abbastabar, Hedayat
AU - Abd-Allah, Foad
AU - Abdelalim, Ahmed
AU - Abdollahi, Mohammad
AU - Abegaz, Hussein
AU - Abiy, Hailemariam Alemu
AU - Abolhassani, Hassan
AU - Abreu, Lucas Guimaraes
AU - Abrigo, Michael R. M.
AU - Abushouk, Abdelrahman I.
AU - Accrombessi, Manfred Mario Koukou
AU - Adabi, Maryam
AU - Adebayo, Oladimeji M.
AU - Adekanmbi, Victor
AU - Adetokunboh, Olatunji O.
AU - Adham, Davoud
AU - Afarideh, Mohsen
AU - Aghaali, Mohammad
AU - Ahmad, Tauseef
AU - Ahmadi, Raman
AU - Ahmadi, Keivan
AU - Ahmed, Muktar Beshir
AU - Alanezi, Fahad Mashhour
AU - Alanzi, Turki M.
AU - Alcalde-Rabanal, Jacqueline Elizabeth
AU - Alemnew, Birhan Tamene
AU - Ali, Beriwan Abdulqadir
AU - Ali, Muhammad
AU - Alijanzadeh, Mehran
AU - Alinia, Cyrus
AU - Alipoor, Reza
AU - Alipour, Vahid
AU - Alizade, Hesam
AU - Aljunid, Syed Mohamed
AU - Almasi, Ali
AU - Almasi-Hashiani, Amir
AU - Al-Mekhlafi, Hesham M.
AU - Altirkawi, Khalid A.
AU - Amare, Bekalu
AU - Amini, Saeed
AU - Amini-Rarani, Mostafa
AU - Amiri, Fatemeh
AU - Amit, Arianna Maever L.
AU - Amugsi, Dickson A.
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AU - Andrei, Catalina Liliana
AU - Anjomshoa, Mina
AU - Ansari, Fereshteh
AU - Ansari-Moghaddam, Alireza
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AU - Antonio, Carl Abelardo T.
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AU - Anvari, Davood
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AU - Aryal, Krishna K.
AU - Arzani, Afsaneh
AU - Asadi-Aliabadi, Mehran
AU - Asgari, Samaneh
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AU - Babaee, Ebrahim
AU - Badawi, Alaa
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AU - Hassanipour, Soheil
AU - Hassankhani, Hadi
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AU - Henry, Nathaniel J.
AU - Herteliu, Claudiu
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AU - Hosseini, Mostafa
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AU - Huda, Tanvir M.
AU - Humayun, Ayesha
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AU - Ikilezi, Gloria
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N1 - Publisher Copyright: © 2020, The Author(s).
PY - 2021/1/21
Y1 - 2021/1/21
N2 - The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
AB - The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2 pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
KW - health surveys
KW - measles
KW - vaccination
UR - http://hdl.handle.net/1959.7/uws:58509
U2 - 10.1038/s41586-020-03043-4
DO - 10.1038/s41586-020-03043-4
M3 - Article
SN - 0028-0836
VL - 589
SP - 415
EP - 419
JO - Nature
JF - Nature
IS - 7842
ER -