Abstract
Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumorassociated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure− function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.
Original language | English |
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Pages (from-to) | 6122-6126 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 141 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- hematite
- iron oxides
- macrophages
- magnetite
- nanoparticles
- tumors