Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management

M. Li; I. G. S. C. Trapika; S. Y. S. Tang; J. L. Cho; Y. Qi; Chun Guang Li; Y. Li; M. Yao; D. Yang; B. Liu; R. Li; P. Yang; G. Ma; P. Ren; X. Huang; D. Xie; S. Chen; M. Li; L. Yang; P. Leng; Y. Huang; G. Q. Li

doi:10.3389/fnut.2021.811870

Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management

M. Li, I. G. S. C. Trapika, S. Y. S. Tang, J. L. Cho, Y. Qi, Chun Guang Li, Y. Li, M. Yao, D. Yang, B. Liu, R. Li, P. Yang, G. Ma, P. Ren, X. Huang, D. Xie, S. Chen, M. Li, L. Yang, P. LengY. Huang, G. Q. Li

Western Sydney University

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Background: Medicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach. Methods: A systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder. Results: Current literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic Î²-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies. Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic Î²-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.

Original language	English
Article number	811870
Number of pages	13
Journal	Frontiers in Nutrition
Volume	8
DOIs	https://doi.org/10.3389/fnut.2021.811870
Publication status	Published - 2022

Open Access - Access Right Statement

© 2022 Li, Trapika, Tang, Cho, Qi, Li, Li, Yao, Yang, Liu, Li, Yang, Ma, Ren, Huang, Xie, Chen, Li, Yang, Leng, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by-nc/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Li, M., Trapika, I. G. S. C., Tang, S. Y. S., Cho, J. L., Qi, Y., Li, C. G., Li, Y., Yao, M., Yang, D., Liu, B., Li, R., Yang, P., Ma, G., Ren, P., Huang, X., Xie, D., Chen, S., Li, M., Yang, L., ... Li, G. Q. (2022). Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management. Frontiers in Nutrition, 8, Article 811870. https://doi.org/10.3389/fnut.2021.811870

@article{20d42fbeda7b416fb76533d2ccc643ca,

title = "Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management",

abstract = "Background: Medicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach. Methods: A systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder. Results: Current literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic {\^I}²-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies. Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic {\^I}²-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.",

author = "M. Li and Trapika, {I. G. S. C.} and Tang, {S. Y. S.} and Cho, {J. L.} and Y. Qi and Li, {Chun Guang} and Y. Li and M. Yao and D. Yang and B. Liu and R. Li and P. Yang and G. Ma and P. Ren and X. Huang and D. Xie and S. Chen and M. Li and L. Yang and P. Leng and Y. Huang and Li, {G. Q.}",

year = "2022",

doi = "10.3389/fnut.2021.811870",

language = "English",

volume = "8",

journal = "Frontiers in Nutrition",

issn = "2296-861X",

publisher = "Frontiers Media SA",

}

Li, M, Trapika, IGSC, Tang, SYS, Cho, JL, Qi, Y, Li, CG, Li, Y, Yao, M, Yang, D, Liu, B, Li, R, Yang, P, Ma, G, Ren, P, Huang, X, Xie, D, Chen, S, Li, M, Yang, L, Leng, P, Huang, Y & Li, GQ 2022, 'Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management', Frontiers in Nutrition, vol. 8, 811870. https://doi.org/10.3389/fnut.2021.811870

TY - JOUR

T1 - Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management

AU - Li, M.

AU - Trapika, I. G. S. C.

AU - Tang, S. Y. S.

AU - Cho, J. L.

AU - Qi, Y.

AU - Li, Chun Guang

AU - Li, Y.

AU - Yao, M.

AU - Yang, D.

AU - Liu, B.

AU - Li, R.

AU - Yang, P.

AU - Ma, G.

AU - Ren, P.

AU - Huang, X.

AU - Xie, D.

AU - Chen, S.

AU - Li, M.

AU - Yang, L.

AU - Leng, P.

AU - Huang, Y.

AU - Li, G. Q.

PY - 2022

Y1 - 2022

N2 - Background: Medicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach. Methods: A systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder. Results: Current literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic Î²-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies. Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic Î²-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.

AB - Background: Medicinal dendrobiums are used popularly in traditional Chinese medicine for the treatment of diabetes, while their active compounds and mechanism remain unclear. This review aimed to evaluate the mechanism and active compounds of medicinal dendrobiums in diabetes management through a systematic approach. Methods: A systematic approach was conducted to search for the mechanism and active phytochemicals in Dendrobium responsible for anti-diabetic actions using databases PubMed, Embase, and SciFinder. Results: Current literature indicates polysaccharides, bibenzyls, phenanthrene, and alkaloids are commonly isolated in Dendrobium genusin which polysaccharides and bibenzyls are most aboundant. Many animal studies have shown that polysaccharides from the species of Dendrobium provide with antidiabetic effects by lowering glucose level and reversing chronic inflammation of T2DM taken orally at 200 mg/kg. Dendrobium polysaccharides protect pancreatic Î²-cell dysfunction and insulin resistance in liver. Dendrobium polysaccharides up-regulate the abundance of short-chain fatty acid to stimulate GLP-1 secretion through gut microbiota. Bibenzyls also have great potency to inhibit the progression of the chronic inflammation in cellular studies. Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic Î²-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.

UR - https://hdl.handle.net/1959.7/uws:76670

U2 - 10.3389/fnut.2021.811870

DO - 10.3389/fnut.2021.811870

M3 - Article

SN - 2296-861X

VL - 8

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

M1 - 811870

ER -

Mechanisms and active compounds polysaccharides and bibenzyls of medicinal dendrobiums for diabetes management

Abstract

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