Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle?

R. A. Lima; G. Desoye; David Simmons; M. N. van Poppel; R. Devlieger; S. Galjaard; R. Corcoy; J. M. Adelantado; F. Dunne; J. Harreiter; A. Kautzky-Willer; P. Damm; E. R. Mathiesen; D. M. Jensen; L. -L. Andersen; M. Tanvig; A. Lapolla; M. G. Dalfra; A. Bertolotto; E. Wender-Ozegowska; A. Zawiejska; D. J. Hill; F. J. Snoek; J. G. M. Jelsma; null The DALI core investigator group

doi:10.1038/s41390-021-01450-5

Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle?

R. A. Lima, G. Desoye, David Simmons, M. N. van Poppel, R. Devlieger, S. Galjaard, R. Corcoy, J. M. Adelantado, F. Dunne, J. Harreiter, A. Kautzky-Willer, P. Damm, E. R. Mathiesen, D. M. Jensen, L. -L. Andersen, M. Tanvig, A. Lapolla, M. G. Dalfra, A. Bertolotto, E. Wender-OzegowskaA. Zawiejska, D. J. Hill, F. J. Snoek, J. G. M. Jelsma, The DALI core investigator group

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated possible mediators underlying lifestyle intervention effects on neonatal adiposity, assessed with sum of skinfolds and cord blood leptin. This is a secondary analysis of the DALI study, a randomised controlled trial in nine European countries. Pregnant women with a pre-pregnancy body mass index of ≥29 kg/m² were randomly assigned to counselling for healthy eating (HE), physical activity (PA), HE&PA combined, or to usual care. We considered five maternal metabolic factors at 24–28 and 35–37 weeks of gestation, and four cord blood factors as possible mediators of the effect of combined HE&PA counselling on neonatal adiposity. From all potential mediators, the intervention only affected cord blood non-esterified fatty acids (NEFA), which was higher in the HE&PA group compared to UC (0.068 (mmol/L), 95% CI: 0.004 to 0.133). Cord blood NEFA did not mediate the HE&PA intervention effects on neonatal sum of skinfolds or cord blood leptin, based on an indirect effect on skinfolds of 0.018 (mm), 95% CI: −0.217 to 0.253 and an indirect effect on leptin of −0.143 (μg/l), 95% CI: −0.560 to 0.273. The Dali study observed reductions in neonatal adiposity in pregnant women with obesity, but we were not able to identify the underlying metabolic pathway.

Original language	English
Pages (from-to)	522-525
Number of pages	4
Journal	Pediatric Research
Volume	91
Issue number	3
DOIs	https://doi.org/10.1038/s41390-021-01450-5
Publication status	Published - Feb 2022

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

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10.1038/s41390-021-01450-5

Cite this

Lima, R. A., Desoye, G., Simmons, D., van Poppel, M. N., Devlieger, R., Galjaard, S., Corcoy, R., Adelantado, J. M., Dunne, F., Harreiter, J., Kautzky-Willer, A., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. .-L., Tanvig, M., Lapolla, A., Dalfra, M. G., Bertolotto, A., ... The DALI core investigator group (2022). Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle? Pediatric Research, 91(3), 522-525. https://doi.org/10.1038/s41390-021-01450-5

@article{03257ec06071460f983660152c9fbda0,

title = "Mediators of lifestyle intervention effects on neonatal adiposity : are we missing a piece of the puzzle?",

abstract = "We evaluated possible mediators underlying lifestyle intervention effects on neonatal adiposity, assessed with sum of skinfolds and cord blood leptin. This is a secondary analysis of the DALI study, a randomised controlled trial in nine European countries. Pregnant women with a pre-pregnancy body mass index of ≥29 kg/m2 were randomly assigned to counselling for healthy eating (HE), physical activity (PA), HE&PA combined, or to usual care. We considered five maternal metabolic factors at 24–28 and 35–37 weeks of gestation, and four cord blood factors as possible mediators of the effect of combined HE&PA counselling on neonatal adiposity. From all potential mediators, the intervention only affected cord blood non-esterified fatty acids (NEFA), which was higher in the HE&PA group compared to UC (0.068 (mmol/L), 95% CI: 0.004 to 0.133). Cord blood NEFA did not mediate the HE&PA intervention effects on neonatal sum of skinfolds or cord blood leptin, based on an indirect effect on skinfolds of 0.018 (mm), 95% CI: −0.217 to 0.253 and an indirect effect on leptin of −0.143 (μg/l), 95% CI: −0.560 to 0.273. The Dali study observed reductions in neonatal adiposity in pregnant women with obesity, but we were not able to identify the underlying metabolic pathway.",

author = "Lima, {R. A.} and G. Desoye and David Simmons and {van Poppel}, {M. N.} and R. Devlieger and S. Galjaard and R. Corcoy and Adelantado, {J. M.} and F. Dunne and J. Harreiter and A. Kautzky-Willer and P. Damm and Mathiesen, {E. R.} and Jensen, {D. M.} and Andersen, {L. -L.} and M. Tanvig and A. Lapolla and Dalfra, {M. G.} and A. Bertolotto and E. Wender-Ozegowska and A. Zawiejska and Hill, {D. J.} and Snoek, {F. J.} and Jelsma, {J. G. M.} and {The DALI core investigator group}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.",

year = "2022",

month = feb,

doi = "10.1038/s41390-021-01450-5",

language = "English",

volume = "91",

pages = "522--525",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Nature Publishing Group",