Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bonnelykke; Melanie C. Matheson; Tune H. Pers; Raquel Granell; David P. Strachan; Alessander Couto Alves; Allen Linneberg; John A. Curtin; Nicole M. Warrington; Marie Standl; Marjan Kerkhof; Iingleif Jonsdottir; Blazenka K. Bukvic; Marika Kaakinen; Patrick Sleimann; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Katherina Schramm; Svetlana Baltic; Eskil Kreiner-Møller; Angela Simpson; Beate St Pourcain; Lachlan Coin; Jennie Hui; Eugene H. Walters; Carla M. T. Tiesler; David L. Duffy; Graham Jones; Susan M. Ring; Wendy L. McArdle; Loren Price; Colin F. Robertson; Juha Pekkanen; Clara S. Tang; Elisabeth Thiering; Grant W. Montgomery; Anna-Liisa Hartikainen; Shyamali C. Dharmage; Lise L. Husemoen; Christian Herder; John P. Kemp; Paul Elliot; Alan James; Melanie Waldenberger; Michael J. Abramson; Benjamin P. Fairfax; Julian C. Knight; Ramneek Gupta; Philip J. Thompson; Patrick Holt; Peter Sly; Joel N. Hirschhorn; Mario Blekic; Stephen Weidinger; Hakon Hakonarsson; Kari Stefansson; Joachim Heinrich; Dirkje S. Postma; Adnan Custovic; Craig E. Pennell; Marjo-Riitta Jarvelin; Gerard H. Koppelman; Nicholas Timpson; Manuel A. Ferreira; Hans Bisgaard; Alan John Henderson

doi:10.1038/ng.2694

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bonnelykke, Melanie C. Matheson, Tune H. Pers, Raquel Granell, David P. Strachan, Alessander Couto Alves, Allen Linneberg, John A. Curtin, Nicole M. Warrington, Marie Standl, Marjan Kerkhof, Iingleif Jonsdottir, Blazenka K. Bukvic, Marika Kaakinen, Patrick Sleimann, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Katherina Schramm, Svetlana Baltic, Eskil Kreiner-MøllerAngela Simpson, Beate St Pourcain, Lachlan Coin, Jennie Hui, Eugene H. Walters, Carla M. T. Tiesler, David L. Duffy, Graham Jones, Susan M. Ring, Wendy L. McArdle, Loren Price, Colin F. Robertson, Juha Pekkanen, Clara S. Tang, Elisabeth Thiering, Grant W. Montgomery, Anna-Liisa Hartikainen, Shyamali C. Dharmage, Lise L. Husemoen, Christian Herder, John P. Kemp, Paul Elliot, Alan James, Melanie Waldenberger, Michael J. Abramson, Benjamin P. Fairfax, Julian C. Knight, Ramneek Gupta, Philip J. Thompson, Patrick Holt, Peter Sly, Joel N. Hirschhorn, Mario Blekic, Stephen Weidinger, Hakon Hakonarsson, Kari Stefansson, Joachim Heinrich, Dirkje S. Postma, Adnan Custovic, Craig E. Pennell, Marjo-Riitta Jarvelin, Gerard H. Koppelman, Nicholas Timpson, Manuel A. Ferreira, Hans Bisgaard, Alan John Henderson

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Abstract

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

Original language	English
Pages (from-to)	902-906
Number of pages	5
Journal	Nature Genetics
Volume	45
Issue number	8
DOIs	https://doi.org/10.1038/ng.2694
Publication status	Published - 2013

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Bonnelykke, K., Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Alves, A. C., Linneberg, A., Curtin, J. A., Warrington, N. M., Standl, M., Kerkhof, M., Jonsdottir, I., Bukvic, B. K., Kaakinen, M., Sleimann, P., Thorleifsson, G., Thorsteinsdottir, U., Schramm, K., Baltic, S., ... Henderson, A. J. (2013). Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45(8), 902-906. https://doi.org/10.1038/ng.2694

@article{11296ab60ffd403dbf8fb3696f3b0773,

title = "Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization",

abstract = "Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.",

author = "Klaus Bonnelykke and Matheson, {Melanie C.} and Pers, {Tune H.} and Raquel Granell and Strachan, {David P.} and Alves, {Alessander Couto} and Allen Linneberg and Curtin, {John A.} and Warrington, {Nicole M.} and Marie Standl and Marjan Kerkhof and Iingleif Jonsdottir and Bukvic, {Blazenka K.} and Marika Kaakinen and Patrick Sleimann and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Katherina Schramm and Svetlana Baltic and Eskil Kreiner-M{\o}ller and Angela Simpson and {St Pourcain}, Beate and Lachlan Coin and Jennie Hui and Walters, {Eugene H.} and Tiesler, {Carla M. T.} and Duffy, {David L.} and Graham Jones and Ring, {Susan M.} and McArdle, {Wendy L.} and Loren Price and Robertson, {Colin F.} and Juha Pekkanen and Tang, {Clara S.} and Elisabeth Thiering and Montgomery, {Grant W.} and Anna-Liisa Hartikainen and Dharmage, {Shyamali C.} and Husemoen, {Lise L.} and Christian Herder and Kemp, {John P.} and Paul Elliot and Alan James and Melanie Waldenberger and Abramson, {Michael J.} and Fairfax, {Benjamin P.} and Knight, {Julian C.} and Ramneek Gupta and Thompson, {Philip J.} and Patrick Holt and Peter Sly and Hirschhorn, {Joel N.} and Mario Blekic and Stephen Weidinger and Hakon Hakonarsson and Kari Stefansson and Joachim Heinrich and Postma, {Dirkje S.} and Adnan Custovic and Pennell, {Craig E.} and Marjo-Riitta Jarvelin and Koppelman, {Gerard H.} and Nicholas Timpson and Ferreira, {Manuel A.} and Hans Bisgaard and Henderson, {Alan John}",

year = "2013",

doi = "10.1038/ng.2694",

language = "English",

volume = "45",

pages = "902--906",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

number = "8",

}

Bonnelykke, K, Matheson, MC, Pers, TH, Granell, R, Strachan, DP, Alves, AC, Linneberg, A, Curtin, JA, Warrington, NM, Standl, M, Kerkhof, M, Jonsdottir, I, Bukvic, BK, Kaakinen, M, Sleimann, P, Thorleifsson, G, Thorsteinsdottir, U, Schramm, K, Baltic, S, Kreiner-Møller, E, Simpson, A, St Pourcain, B, Coin, L, Hui, J, Walters, EH, Tiesler, CMT, Duffy, DL, Jones, G, Ring, SM, McArdle, WL, Price, L, Robertson, CF, Pekkanen, J, Tang, CS, Thiering, E, Montgomery, GW, Hartikainen, A-L, Dharmage, SC, Husemoen, LL, Herder, C, Kemp, JP, Elliot, P, James, A, Waldenberger, M, Abramson, MJ, Fairfax, BP, Knight, JC, Gupta, R, Thompson, PJ, Holt, P, Sly, P, Hirschhorn, JN, Blekic, M, Weidinger, S, Hakonarsson, H, Stefansson, K, Heinrich, J, Postma, DS, Custovic, A, Pennell, CE, Jarvelin, M-R, Koppelman, GH, Timpson, N, Ferreira, MA, Bisgaard, H & Henderson, AJ 2013, 'Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization', Nature Genetics, vol. 45, no. 8, pp. 902-906. https://doi.org/10.1038/ng.2694

TY - JOUR

T1 - Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

AU - Bonnelykke, Klaus

AU - Matheson, Melanie C.

AU - Pers, Tune H.

AU - Granell, Raquel

AU - Strachan, David P.

AU - Alves, Alessander Couto

AU - Linneberg, Allen

AU - Curtin, John A.

AU - Warrington, Nicole M.

AU - Standl, Marie

AU - Kerkhof, Marjan

AU - Jonsdottir, Iingleif

AU - Bukvic, Blazenka K.

AU - Kaakinen, Marika

AU - Sleimann, Patrick

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Schramm, Katherina

AU - Baltic, Svetlana

AU - Kreiner-Møller, Eskil

AU - Simpson, Angela

AU - St Pourcain, Beate

AU - Coin, Lachlan

AU - Hui, Jennie

AU - Walters, Eugene H.

AU - Tiesler, Carla M. T.

AU - Duffy, David L.

AU - Jones, Graham

AU - Ring, Susan M.

AU - McArdle, Wendy L.

AU - Price, Loren

AU - Robertson, Colin F.

AU - Pekkanen, Juha

AU - Tang, Clara S.

AU - Thiering, Elisabeth

AU - Montgomery, Grant W.

AU - Hartikainen, Anna-Liisa

AU - Dharmage, Shyamali C.

AU - Husemoen, Lise L.

AU - Herder, Christian

AU - Kemp, John P.

AU - Elliot, Paul

AU - James, Alan

AU - Waldenberger, Melanie

AU - Abramson, Michael J.

AU - Fairfax, Benjamin P.

AU - Knight, Julian C.

AU - Gupta, Ramneek

AU - Thompson, Philip J.

AU - Holt, Patrick

AU - Sly, Peter

AU - Hirschhorn, Joel N.

AU - Blekic, Mario

AU - Weidinger, Stephen

AU - Hakonarsson, Hakon

AU - Stefansson, Kari

AU - Heinrich, Joachim

AU - Postma, Dirkje S.

AU - Custovic, Adnan

AU - Pennell, Craig E.

AU - Jarvelin, Marjo-Riitta

AU - Koppelman, Gerard H.

AU - Timpson, Nicholas

AU - Ferreira, Manuel A.

AU - Bisgaard, Hans

AU - Henderson, Alan John

PY - 2013

Y1 - 2013

N2 - Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

AB - Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

UR - http://handle.uws.edu.au:8081/1959.7/530422

U2 - 10.1038/ng.2694

DO - 10.1038/ng.2694

M3 - Article

SN - 1546-1718

SN - 1061-4036

VL - 45

SP - 902

EP - 906

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

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