Metastable control of cooling crystallisation

Linh T. T. Vu; Jim Hourigan; Robert W. Sleigh; H. Ming Ang; Moses O. Tade

Metastable control of cooling crystallisation

Linh T. T. Vu, Jim Hourigan, Robert W. Sleigh, H. Ming Ang, Moses O. Tade

Research output: Chapter in Book / Conference Paper › Conference Paper

Abstract

The paper studies the metastable control of cooling slow- and fast-growth crystalline compounds, which have: low solubility at 25Â°C, high solubility parameters and a detectable metastable zone. Nyvlt's and alternative methods are applied to measure the metastable limits. An optimal control problem is developed in GAMS and solved for the optimal cooling temperature set points. Various cooling and seeding strategies are implemented in a laboratory-scale crystalliser to compare the yields and Crystal Size Distributions (CSD). For both compounds, slow cooling with initial fine seeds is the optimal crystallisation strategy in batches, which can achieve the highest yield and the narrowest range of particle size. The successful laboratory-scale results will lead to further pilot- and industrial-scale investigations.

Original language	English
Title of host publication	European Symposium on Computer Aided Process Engineering 13 : 36th European Symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland
Publisher	Elsevier Science
Number of pages	6
ISBN (Print)	044451368X
Publication status	Published - 2003
Event	European Symposium on Computer Aided Process Engineering - Duration: 1 Jan 2005 → …

Conference

Conference	European Symposium on Computer Aided Process Engineering
Period	1/01/05 → …

Cite this

@inproceedings{a22dd4a2e0fc4b41b61a83ac26b2bbf6,

title = "Metastable control of cooling crystallisation",

abstract = "The paper studies the metastable control of cooling slow- and fast-growth crystalline compounds, which have: low solubility at 25{\^A}°C, high solubility parameters and a detectable metastable zone. Nyvlt's and alternative methods are applied to measure the metastable limits. An optimal control problem is developed in GAMS and solved for the optimal cooling temperature set points. Various cooling and seeding strategies are implemented in a laboratory-scale crystalliser to compare the yields and Crystal Size Distributions (CSD). For both compounds, slow cooling with initial fine seeds is the optimal crystallisation strategy in batches, which can achieve the highest yield and the narrowest range of particle size. The successful laboratory-scale results will lead to further pilot- and industrial-scale investigations.",

author = "Vu, {Linh T. T.} and Jim Hourigan and Sleigh, {Robert W.} and Ang, {H. Ming} and Tade, {Moses O.}",

year = "2003",

language = "English",

isbn = "044451368X",

booktitle = "European Symposium on Computer Aided Process Engineering 13 : 36th European Symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland",

publisher = "Elsevier Science",

note = "European Symposium on Computer Aided Process Engineering ; Conference date: 01-01-2005",

}

Vu, LTT, Hourigan, J, Sleigh, RW, Ang, HM & Tade, MO 2003, Metastable control of cooling crystallisation. in European Symposium on Computer Aided Process Engineering 13 : 36th European Symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland. Elsevier Science, European Symposium on Computer Aided Process Engineering, 1/01/05.

Metastable control of cooling crystallisation. / Vu, Linh T. T.; Hourigan, Jim; Sleigh, Robert W. et al.
European Symposium on Computer Aided Process Engineering 13 : 36th European Symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland. Elsevier Science, 2003.

Research output: Chapter in Book / Conference Paper › Conference Paper

TY - GEN

T1 - Metastable control of cooling crystallisation

AU - Vu, Linh T. T.

AU - Hourigan, Jim

AU - Sleigh, Robert W.

AU - Ang, H. Ming

AU - Tade, Moses O.

PY - 2003

Y1 - 2003

N2 - The paper studies the metastable control of cooling slow- and fast-growth crystalline compounds, which have: low solubility at 25Â°C, high solubility parameters and a detectable metastable zone. Nyvlt's and alternative methods are applied to measure the metastable limits. An optimal control problem is developed in GAMS and solved for the optimal cooling temperature set points. Various cooling and seeding strategies are implemented in a laboratory-scale crystalliser to compare the yields and Crystal Size Distributions (CSD). For both compounds, slow cooling with initial fine seeds is the optimal crystallisation strategy in batches, which can achieve the highest yield and the narrowest range of particle size. The successful laboratory-scale results will lead to further pilot- and industrial-scale investigations.

AB - The paper studies the metastable control of cooling slow- and fast-growth crystalline compounds, which have: low solubility at 25Â°C, high solubility parameters and a detectable metastable zone. Nyvlt's and alternative methods are applied to measure the metastable limits. An optimal control problem is developed in GAMS and solved for the optimal cooling temperature set points. Various cooling and seeding strategies are implemented in a laboratory-scale crystalliser to compare the yields and Crystal Size Distributions (CSD). For both compounds, slow cooling with initial fine seeds is the optimal crystallisation strategy in batches, which can achieve the highest yield and the narrowest range of particle size. The successful laboratory-scale results will lead to further pilot- and industrial-scale investigations.

UR - http://handle.uws.edu.au:8081/1959.7/11144

M3 - Conference Paper

SN - 044451368X

BT - European Symposium on Computer Aided Process Engineering 13 : 36th European Symposium of the Working Party on Computer Aided Process Engineering : ESCAPE-13, 1-4 June, 2003, Lappeenranta, Finland

PB - Elsevier Science

T2 - European Symposium on Computer Aided Process Engineering

Y2 - 1 January 2005

ER -

Metastable control of cooling crystallisation

Abstract

Conference

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