Method of Screening for Inhibitors of sPLA2-IIA

Kieran Scott; W. Bret Church; Lawrence K. Lee

Method of Screening for Inhibitors of sPLA2-IIA

Kieran Scott (Inventor), W. Bret Church (Inventor), Lawrence K. Lee (Inventor)

School of Medicine

Research output: Patent

Abstract

The present invention relates generally to structural studies of the group IIA human secreted PLA2 (s PLA2-IIA). More particularly, the present invention relates to the crystal structure of s PLA2-IIA in complex with inhibitor molecules, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate s PLA2-IIA.

Original language	English
Patent number	WO 2011/160189 A1
Priority date	25/06/10
Filing date	24/06/11
Publication status	Published - 2011

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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2011160189

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title = "Method of Screening for Inhibitors of sPLA2-IIA",

abstract = "The present invention relates generally to structural studies of the group IIA human secreted PLA2 (s PLA2-IIA). More particularly, the present invention relates to the crystal structure of s PLA2-IIA in complex with inhibitor molecules, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate s PLA2-IIA.",

author = "Kieran Scott and Church, {W. Bret} and Lee, {Lawrence K.}",

year = "2011",

language = "English",

publisher = "World Intellectual Property Organization ",

type = "Patent",

note = "WO 2011/160189 A1",

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TY - PAT

T1 - Method of Screening for Inhibitors of sPLA2-IIA

AU - Scott, Kieran

AU - Church, W. Bret

AU - Lee, Lawrence K.

PY - 2011

Y1 - 2011

N2 - The present invention relates generally to structural studies of the group IIA human secreted PLA2 (s PLA2-IIA). More particularly, the present invention relates to the crystal structure of s PLA2-IIA in complex with inhibitor molecules, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate s PLA2-IIA.

AB - The present invention relates generally to structural studies of the group IIA human secreted PLA2 (s PLA2-IIA). More particularly, the present invention relates to the crystal structure of s PLA2-IIA in complex with inhibitor molecules, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate s PLA2-IIA.

M3 - Patent

M1 - WO 2011/160189 A1

Y2 - 2011/06/24

PB - World Intellectual Property Organization

ER -

Method of Screening for Inhibitors of sPLA2-IIA

Abstract

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