Microchip-based synthesis and analysis: Control of multicomponent reaction products and intermediates

M. C. Mitchell; V. Spikmans; A. J. De Mello

doi:10.1039/b007397k

Microchip-based synthesis and analysis: Control of multicomponent reaction products and intermediates

M. C. Mitchell, V. Spikmans, A. J. De Mello

Imperial College London

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

A miniaturised-SYNthesis and Total Analysis System (μSYNTAS) was used for the solution-phase synthesis and on-line analysis (TOF-MS) of Ugi multicomponent reaction (MCR) products. This approach provides an unusually high degree of control of the MCR and delivers detailed, novel information on reaction intermediates in real-time. Specifically, the Ugi 4 component condensation (4CC) involving the reaction of an amine, acid, aldehyde and isocyanide species was performed at room temperature in a controllable fashion. Furthermore, observation of the nitrilium intermediate, cyclohexyl(2-piperidin-1-ylethylidyne)ammonium chloride, is presented for the first time.

Original language	English
Pages (from-to)	24-27
Number of pages	4
Journal	Analyst
Volume	126
Issue number	1
DOIs	https://doi.org/10.1039/b007397k
Publication status	Published - 2001
Externally published	Yes

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Microchip-based synthesis and analysis: Control of multicomponent reaction products and intermediates

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