TY - JOUR
T1 - Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon
AU - Li, Puwang
AU - Yang, Ziming
AU - Wang, Yichao
AU - Peng, Zheng
AU - Li, Sidong
AU - Kong, Lingxue
AU - Wang, Qinghuang
PY - 2015
Y1 - 2015
N2 - Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35m. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.
AB - Folate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35m. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.
UR - https://hdl.handle.net/1959.7/uws:71499
U2 - 10.3109/02652048.2014.944947
DO - 10.3109/02652048.2014.944947
M3 - Article
SN - 0265-2048
VL - 32
SP - 40
EP - 45
JO - Journal of Microencapsulation
JF - Journal of Microencapsulation
IS - 1
ER -
