Midlife managerial experience is linked to late life hippocampal morphology and function

C. Suo; N. Gates; M. Fiatarone Singh; N. Saigal; G. C. Wilson; J. Meiklejohn; P. Sachdev; H. Brodaty; W. Wen; N. Singh; B. T. Baune; M. Baker; N. Foroughi; Y. Wang; Michael J. Valenzuela

doi:10.1007/s11682-016-9649-8

Midlife managerial experience is linked to late life hippocampal morphology and function

C. Suo, N. Gates, M. Fiatarone Singh, N. Saigal, G. C. Wilson, J. Meiklejohn, P. Sachdev, H. Brodaty, W. Wen, N. Singh, B. T. Baune, M. Baker, N. Foroughi, Y. Wang, Michael J. Valenzuela

Western Sydney University

University of Sydney

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation.

Original language	English
Pages (from-to)	333-345
Number of pages	13
Journal	Brain Imaging and Behavior
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/s11682-016-9649-8
Publication status	Published - 2017

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This article is distributed under the terms of the Creative C o m m o n s A t t r i b u t i o n 4 . 0 I n t e r n a t i o n a l L i c e n s e ( h t t p : / / creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

Cognitive lifestyle; Hippocampal functional connectivity; Hippocampal morphometry; Hippocampal volume; Managerial experience; Memory

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10.1007/s11682-016-9649-8

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Suo, C., Gates, N., Singh, M. F., Saigal, N., Wilson, G. C., Meiklejohn, J., Sachdev, P., Brodaty, H., Wen, W., Singh, N., Baune, B. T., Baker, M., Foroughi, N., Wang, Y., & Valenzuela, M. J. (2017). Midlife managerial experience is linked to late life hippocampal morphology and function. Brain Imaging and Behavior, 11(2), 333-345. https://doi.org/10.1007/s11682-016-9649-8

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abstract = "An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation.",

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AU - Suo, C.

AU - Gates, N.

AU - Singh, M. Fiatarone

AU - Saigal, N.

AU - Wilson, G. C.

AU - Meiklejohn, J.

AU - Sachdev, P.

AU - Brodaty, H.

AU - Wen, W.

AU - Singh, N.

AU - Baune, B. T.

AU - Baker, M.

AU - Foroughi, N.

AU - Wang, Y.

AU - Valenzuela, Michael J.

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AB - An active cognitive lifestyle has been suggested to have a protective role in the long-term maintenance of cognition. Amongst healthy older adults, more managerial or supervisory experiences in midlife are linked to a slower hippocampal atrophy rate in late life. Yet whether similar links exist in individuals with Mild Cognitive Impairment (MCI) is not known, nor whether these differences have any functional implications. 68 volunteers from the Sydney SMART Trial, diagnosed with non-amnestic MCI, were divided into high and low managerial experience (HME/LME) during their working life. All participants underwent neuropsychological testing, structural and resting-state functional MRI. Group comparisons were performed on hippocampal volume, morphology, hippocampal seed-based functional connectivity, memory and executive function and self-ratings of memory proficiency. HME was linked to better memory function (p = 0.024), mediated by larger hippocampal volume (p = 0.025). More specifically, deformation analysis found HME had relatively more volume in the CA1 sub-region of the hippocampus (p < 0.05). Paradoxically, this group rated their memory proficiency worse (p = 0.004), a result correlated with diminished functional connectivity between the right hippocampus and right prefrontal cortex (p < 0.001). Finally, hierarchical regression modelling substantiated this double dissociation.

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JO - Brain Imaging and Behavior

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ER -

Midlife managerial experience is linked to late life hippocampal morphology and function

Abstract

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