Mirror symmetry of peripheral monochromatic aberrations in fellow eyes of isomyopes and anisomyopes

PURPOSE. To investigate mirror symmetry of peripheral ocular aberrations in fellow eyes of isoand anisomyopes. METHODS. Peripheral aberration was measured over the central 42⁰ x 32⁰ visual field for a 5- mm pupil in both eyes of 19 isomyopic (spherical equivalent refraction M [right/left]:-2.5 ± 2.1 diopters [D]/-2.7 ± 2.3 D) and 10 anisomyopic (M:-4.0 ± 1.8 D/-4.3 ± 2.8 D) young adults. Isomyopes had less than 1.0 D fellow eye refraction difference and anisomyopes had between 1.0 D and 2.6 D fellow eye differences (mean difference: 1.3 ± 0.6 D). Orthogonal regression of Zernike coefficients determined right-left eye correlations in isomyopes. For anisomyopes, higher and lower myopic eye coefficients were compared. RESULTS. For isomyopes, the percentages of visual field locations with significant coefficient correlations between fellow eyes varied from 100% for astigmatism (C2 2 ) to 18% for tetrafoil (C4 4 ). Positive correlations were found for C2 2, C1 3 , C3 3 , C0 4 , C2 4 , and C4 4 , and negative correlations were found for C2 2 , C1 3 , C3 3 , C4 4 , and C2 4 coefficients, indicating that the signs are different for corresponding locations of fellow eyes for the last five of these coefficients. Slopes of correlations were not different from 6 1, except for C2 2 , C1 3 , and C4 4 (þ0.95, 0.97, and þ0.52, respectively). In anisomyopes, significant but small fellow eye differences were found for only C0 4 and C2 4 coefficients, with significant interactions between anisometropia and field position for only two coefficients. CONCLUSIONS. Peripheral aberration coefficients across the visual field show mirror symmetry in isomyopes, and in a pooled data set the coefficients with negative correlations require sign changes for left eye data. Anisometropia contributes no more to peripheral aberration differences between fellow eyes than could be expected on the basis of refraction differences between people.