Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

Loo-Teck Ng; Eiji Yuba; Kenji Kono

Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

Loo-Teck Ng, Eiji Yuba, Kenji Kono

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 Ã‚Â°C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena.

Original language	English
Pages (from-to)	1015-1025
Number of pages	11
Journal	Research on Chemical Intermediates
Volume	35
Issue number	45543
Publication status	Published - 2009

Keywords

acrylic acid
controlled-release
liposomes
pH-responsive
polyampholytes
polymers

Cite this

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title = "Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs",

abstract = "Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 {\~A}‚{\^A}°C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena.",

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author = "Loo-Teck Ng and Eiji Yuba and Kenji Kono",

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pages = "1015--1025",

journal = "Research on Chemical Intermediates",

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TY - JOUR

T1 - Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

AU - Ng, Loo-Teck

AU - Yuba, Eiji

AU - Kono, Kenji

PY - 2009

Y1 - 2009

N2 - Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 Ã‚Â°C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena.

AB - Ampholytic polymers comprised of 2-(diethylamino)ethyl methacrylate (DEAEMA) and acrylic acid (AA) in varying molar ratios were used to modify egg yolk phosphatidylcholine (EYPC) liposomes previously encapsulated with pyranine. The modified EYPC liposomes were found to be pH responsive. The critical pH values at which the pyranine release from these liposomes at 37 Ã‚Â°C were observed to decrease with increasing DEAEMA content in the polymers. Explanations were given for these phenomena.

KW - acrylic acid

KW - controlled-release

KW - liposomes

KW - pH-responsive

KW - polyampholytes

KW - polymers

UR - http://handle.uws.edu.au:8081/1959.7/501526

M3 - Article

SN - 0922-6168

VL - 35

SP - 1015

EP - 1025

JO - Research on Chemical Intermediates

JF - Research on Chemical Intermediates

IS - 45543

ER -

Modification of liposome surface with pH-responsive polyampholytes for the controlled-release of drugs

Abstract

Keywords

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