Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA

Mitchell R. O&apos;Connell; Marylene Vandevenne; Cuong D. Nguyen; Jacqueline M. Matthews; Roland Gamsjaeger; David J. Segal; Joel P. MacKay

doi:10.1002/anie.201200866

Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA

Mitchell R. O'Connell, Marylene Vandevenne, Cuong D. Nguyen, Jacqueline M. Matthews, Roland Gamsjaeger, David J. Segal, Joel P. MacKay

School of Science

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.

Original language	English
Pages (from-to)	5371-5375
Number of pages	5
Journal	Angewandte Chemie (International Edition)
Volume	51
Issue number	22
DOIs	https://doi.org/10.1002/anie.201200866
Publication status	Published - 2012

Keywords

amino acids
genetics
metabolism
modular assembly
molecules
protein design
proteins
zinc

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10.1002/anie.201200866

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title = "Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA",

abstract = "Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.",

keywords = "amino acids, genetics, metabolism, modular assembly, molecules, protein design, proteins, zinc",

author = "O'Connell, {Mitchell R.} and Marylene Vandevenne and Nguyen, {Cuong D.} and Matthews, {Jacqueline M.} and Roland Gamsjaeger and Segal, {David J.} and MacKay, {Joel P.}",

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volume = "51",

pages = "5371--5375",

journal = "Angewandte Chemie (International Edition)",

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T1 - Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA

AU - O'Connell, Mitchell R.

AU - Vandevenne, Marylene

AU - Nguyen, Cuong D.

AU - Matthews, Jacqueline M.

AU - Gamsjaeger, Roland

AU - Segal, David J.

AU - MacKay, Joel P.

PY - 2012

Y1 - 2012

N2 - Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.

AB - Fingering RNA: To study the function of the variety of RNA species that have been discovered recently, sequence-specific RNA-binding molecules with tunable specificity are required. Here, the use of zinc fingers (ZFs) from the splicing factors ZRANB2 and RBM5 as potential modules for the assembly of sequence-specific RNA-binding molecules is demonstrated.

KW - amino acids

KW - genetics

KW - metabolism

KW - modular assembly

KW - molecules

KW - protein design

KW - proteins

KW - zinc

UR - http://handle.uws.edu.au:8081/1959.7/516174

U2 - 10.1002/anie.201200866

DO - 10.1002/anie.201200866

M3 - Article

C2 - 22517726

SN - 1433-7851

VL - 51

SP - 5371

EP - 5375

JO - Angewandte Chemie (International Edition)

JF - Angewandte Chemie (International Edition)

IS - 22

ER -

Modular assembly of RanBP2-Type zinc finger domains to target single-stranded RNA

Abstract

Keywords

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