TY - JOUR
T1 - Modulation of cytokine production and complement activity by biopolymers extracted from medicinal plants
AU - Jeong, Sang Chul
AU - Koyyalamudi, Sundar Rao
AU - Hughes, J. Margaret
AU - Khoo, Cheang
AU - Bailey, Trevor
AU - Park, Jong Pil
AU - Song, Chi Hyun
PY - 2013
Y1 - 2013
N2 - This study evaluates the anti-inflammatory activities of the extracts obtained from the medicinal plants Aster tataricus, Pinellia ternata, Ostericum koreanum, Platicodon grandiflorum, Asarum sieboldii, Tussilage farfara, and Acanthopanax sessiliflorus. These plants are used in Korea to treat inflammatory and respiratory ailments, including asthma. The hot water extract (HWE) of A. sessiliflorus inhibited production of IFN-γ, IL-2, IL-4 and IL-5. The HWE of A. tataricus, O. koreanum, P. grandiflorum, A. sieboldii and T. farfara had similar inhibitory effects on IFN-γ and IL-5. The endo-polysaccharide (ENP) screened were less active than the HWE and had varying effects on the production of cytokines. The HWE fractions from all the plants except that from P.grandiflorum had marked anti-complement activity at a concentration of 1000 µg/ml. The ENP of A. sieboldii, T. farfara and A. sessiliflorus exhibited significant anti-complement activity compared to the positive control.
AB - This study evaluates the anti-inflammatory activities of the extracts obtained from the medicinal plants Aster tataricus, Pinellia ternata, Ostericum koreanum, Platicodon grandiflorum, Asarum sieboldii, Tussilage farfara, and Acanthopanax sessiliflorus. These plants are used in Korea to treat inflammatory and respiratory ailments, including asthma. The hot water extract (HWE) of A. sessiliflorus inhibited production of IFN-γ, IL-2, IL-4 and IL-5. The HWE of A. tataricus, O. koreanum, P. grandiflorum, A. sieboldii and T. farfara had similar inhibitory effects on IFN-γ and IL-5. The endo-polysaccharide (ENP) screened were less active than the HWE and had varying effects on the production of cytokines. The HWE fractions from all the plants except that from P.grandiflorum had marked anti-complement activity at a concentration of 1000 µg/ml. The ENP of A. sieboldii, T. farfara and A. sessiliflorus exhibited significant anti-complement activity compared to the positive control.
KW - endo, polysaccharide
KW - anti, inflammatory agents
KW - cytokines
UR - http://handle.uws.edu.au:8081/1959.7/528037
UR - http://www.inforesights.com/phytopharmacology/files/pp4v1i2.pdf
M3 - Article
SN - 2046-1194
VL - 4
SP - 19
EP - 30
JO - Phytopharmacology
JF - Phytopharmacology
IS - 1
ER -