Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju, Zeinab G. Khalil, Andrew M. Piggott, Antje Blumenthal, Donald L. Gardiner, Tina S. Skinner-Adams, Robert J. Capon

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    A marine-derived Streptomyces sp. (CMBM0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey’s analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10−50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.
    Original languageEnglish
    Pages (from-to)1716-1719
    Number of pages4
    JournalOrganic Letters
    Volume16
    Issue number6
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Dive into the research topics of 'Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)'. Together they form a unique fingerprint.

    Cite this