Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju; Zeinab G. Khalil; Andrew M. Piggott; Antje Blumenthal; Donald L. Gardiner; Tina S. Skinner-Adams; Robert J. Capon

doi:10.1021/ol5003913

Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Ritesh Raju
, Zeinab G. Khalil
, Andrew M. Piggott
, Antje Blumenthal
, Donald L. Gardiner
, Tina S. Skinner-Adams
, Robert J. Capon

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

A marine-derived Streptomyces sp. (CMBM0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10âˆ’50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.

Original language	English
Pages (from-to)	1716-1719
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	6
DOIs	https://doi.org/10.1021/ol5003913
Publication status	Published - 2014

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title = "Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)",

abstract = "A marine-derived Streptomyces sp. (CMBM0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10{\^a}ˆ{\textquoteright}50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.",

author = "Ritesh Raju and Khalil, \{Zeinab G.\} and Piggott, \{Andrew M.\} and Antje Blumenthal and Gardiner, \{Donald L.\} and Skinner-Adams, \{Tina S.\} and Capon, \{Robert J.\}",

year = "2014",

doi = "10.1021/ol5003913",

language = "English",

volume = "16",

pages = "1716--1719",

journal = "Organic Letters",

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T1 - Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

AU - Raju, Ritesh

AU - Khalil, Zeinab G.

AU - Piggott, Andrew M.

AU - Blumenthal, Antje

AU - Gardiner, Donald L.

AU - Skinner-Adams, Tina S.

AU - Capon, Robert J.

PY - 2014

Y1 - 2014

N2 - A marine-derived Streptomyces sp. (CMBM0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10âˆ’50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.

AB - A marine-derived Streptomyces sp. (CMBM0244) isolated from a sediment collected off South Molle Island, Queensland, produced mollemycin A (1) as a new first in class glyco-hexadepsipeptide-polyketide. The structure of 1 was assigned by detailed spectroscopic analysis, supported by chemical derivatization and degradation, and C3 Marfey's analysis. Mollemycin A (1) exhibits exceptionally potent and selective growth inhibitory activity against Gram-positive and Gram-negative bacteria (IC50 10âˆ’50 nM) and drug-sensitive (3D7; IC50 7 nM) and multidrug-resistant (Dd2; IC50 9 nM) clones of the malaria parasite Plasmodium falciparum.

UR - http://handle.uws.edu.au:8081/1959.7/544554

U2 - 10.1021/ol5003913

DO - 10.1021/ol5003913

M3 - Article

C2 - 24611932

SN - 1523-7052

VL - 16

SP - 1716

EP - 1719

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Mollemycin A : an antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Abstract

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