Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017

Christopher E. Troeger; Brigette F. Blacker; Ibrahim A. Khalil; Stephanie R. M. Zimsen; Samuel B. Albertson; Degu Abate; Jemal Abdela; Tara Ballav Adhikari; Sargis Aghasi Aghayan; Sutapa Agrawal; Alireza Ahmadi; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Ayman Al-Eyadhy; Rajaa M. Al-Raddadi; Fares Alahdab; Kefyalew Addis Alene; Syed Mohamed Aljunid; Nelson Alvis-Guzman; Nahla Hamed Anber; Mina Anjomshoa; Carl Abelardo T. Antonio; Olatunde Aremu; Hagos Tasew Atalay; Suleman Atique; Engi F. Attia; Euripide F. G. A. Avokpaho; Ashish Awasthi; Arefeh Babazadeh; Hamid Badali; Alaa Badawi; Joseph Adel Mattar Banoub; Aleksandra Barac; Quique Bassat; Neeraj Bedi; Abate Bekele Belachew; Derrick A. Bennett; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Ali Bijani; Felix Carvalho; Carlos A. Castañeda-Orjuela; Devasahayam J. Christopher; Lalit Dandona; Rakhi Dandona; Anh Kim Dang; Ahmad Daryani; Meaza Girma Degefa; Feleke Mekonnen Demeke; Meghnath Dhimal; Shirin Djalalinia; David Teye Doku; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Dumessa Edessa; Maysaa El Sayed Zaki; Hamed Fakhim; Eduarda Fernandes; Florian Fischer; Luisa Sorio Flor; Kyle J. Foreman; Teklu Gebrehiwo Gebremichael; Demeke Geremew; Keyghobad Ghadiri; Alessandra C. Goulart; Jingwen Guo; Giang Hai Ha; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Samer Hamidi; Hamid Yimam Hassen; Chi Linh Hoang; Nobuyuki Horita; Mihaela Hostiuc; Seyed Sina Naghibi Irvani; Ravi Prakash Jha; Jost B. Jonas; Amaha Kahsay; Andre Karch; Amir Kasaeian; Tesfaye Dessale Kassa; Adane Teshome Kefale; Yousef Saleh Khader; Ejaz Ahmad Khan; Gulfaraz Khan; Md. Nuruzzaman Khan; Young-Ho Khang; Abdullah T. Khoja; Jagdish Khubchandani; Ruth W. Kimokoti; Adnan Kisa; Luke D. Knibbs; Sonali Kochhar; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Barthelemy Kaute Defo; G. Anil Kumar; Dharmesh Kumar Lal; Prabhat Lamichhane; Cheru Tesema Leshargie; Miriam Levi; Shanshan Li; Erlyn Rachelle King Macarayan; Marek Majdan; Varshil Mehta; Addisu Melese; Ziad A. Memish; Desalegn Tadese Mengistu; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; George J. Milne; Branko Milosevic; Erkin M. Mirrakhimov; Babak Moazen; Karzan Abdulmuhsin Mohammad; Shafiu Mohammed; Lorenzo Monasta; Lidia Morawska; Seyyed Meysam Mousavi; Oumer Sada S. Muhammed; Srinivas Murthy; Ghulam Mustafa; Aliya Naheed; Huong Lan Thi Nguyen; Nam Ba Nguyen; Son Hoang Nguyen; Trang Huyen Nguyen; Muhammad Imran Nisar; Molly R. Nixon; Felix Akpojene Ogbo; null et al

doi:10.1016/S2213-2600(18)30496-X

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017

Christopher E. Troeger, Brigette F. Blacker, Ibrahim A. Khalil, Stephanie R. M. Zimsen, Samuel B. Albertson, Degu Abate, Jemal Abdela, Tara Ballav Adhikari, Sargis Aghasi Aghayan, Sutapa Agrawal, Alireza Ahmadi, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Ayman Al-Eyadhy, Rajaa M. Al-Raddadi, Fares Alahdab, Kefyalew Addis Alene, Syed Mohamed Aljunid, Nelson Alvis-GuzmanNahla Hamed Anber, Mina Anjomshoa, Carl Abelardo T. Antonio, Olatunde Aremu, Hagos Tasew Atalay, Suleman Atique, Engi F. Attia, Euripide F. G. A. Avokpaho, Ashish Awasthi, Arefeh Babazadeh, Hamid Badali, Alaa Badawi, Joseph Adel Mattar Banoub, Aleksandra Barac, Quique Bassat, Neeraj Bedi, Abate Bekele Belachew, Derrick A. Bennett, Krittika Bhattacharyya, Zulfiqar A. Bhutta, Ali Bijani, Felix Carvalho, Carlos A. Castañeda-Orjuela, Devasahayam J. Christopher, Lalit Dandona, Rakhi Dandona, Anh Kim Dang, Ahmad Daryani, Meaza Girma Degefa, Feleke Mekonnen Demeke, Meghnath Dhimal, Shirin Djalalinia, David Teye Doku, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, Dumessa Edessa, Maysaa El Sayed Zaki, Hamed Fakhim, Eduarda Fernandes, Florian Fischer, Luisa Sorio Flor, Kyle J. Foreman, Teklu Gebrehiwo Gebremichael, Demeke Geremew, Keyghobad Ghadiri, Alessandra C. Goulart, Jingwen Guo, Giang Hai Ha, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Hamid Yimam Hassen, Chi Linh Hoang, Nobuyuki Horita, Mihaela Hostiuc, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Jost B. Jonas, Amaha Kahsay, Andre Karch, Amir Kasaeian, Tesfaye Dessale Kassa, Adane Teshome Kefale, Yousef Saleh Khader, Ejaz Ahmad Khan, Gulfaraz Khan, Md. Nuruzzaman Khan, Young-Ho Khang, Abdullah T. Khoja, Jagdish Khubchandani, Ruth W. Kimokoti, Adnan Kisa, Luke D. Knibbs, Sonali Kochhar, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Barthelemy Kaute Defo, G. Anil Kumar, Dharmesh Kumar Lal, Prabhat Lamichhane, Cheru Tesema Leshargie, Miriam Levi, Shanshan Li, Erlyn Rachelle King Macarayan, Marek Majdan, Varshil Mehta, Addisu Melese, Ziad A. Memish, Desalegn Tadese Mengistu, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, George J. Milne, Branko Milosevic, Erkin M. Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Lorenzo Monasta, Lidia Morawska, Seyyed Meysam Mousavi, Oumer Sada S. Muhammed, Srinivas Murthy, Ghulam Mustafa, Aliya Naheed, Huong Lan Thi Nguyen, Nam Ba Nguyen, Son Hoang Nguyen, Trang Huyen Nguyen, Muhammad Imran Nisar, Molly R. Nixon, Felix Akpojene Ogbo, et al

Western Sydney University

Research output: Contribution to journal › Article › peer-review

385 Citations (Scopus)

Abstract

Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods: We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings: Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000–200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16Â·4 deaths per 100 000 [95% UI 11Â·6–21Â·9]), and the highest rate among all ages was in eastern Europe (5Â·2 per 100 000 population [95% UI 3Â·5–7Â·2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000–22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000–259 851 000). We estimated that 11Â·5% (95% UI 10Â·0–12Â·9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000–73 864 000) episodes and 8 172 000 severe episodes (5 000 000–13 296 000). Interpretation: This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Funding: Bill & Melinda Gates Foundation.

Original language	English
Pages (from-to)	69-89
Number of pages	21
Journal	The Lancet Respiratory Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S2213-2600(18)30496-X
Publication status	Published - 2019

Open Access - Access Right Statement

Keywords

World health
health surveys
influenza
respiratory infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S2213-2600(18)30496-X

Cite this

Troeger, C. E., Blacker, B. F., Khalil, I. A., Zimsen, S. R. M., Albertson, S. B., Abate, D., Abdela, J., Adhikari, T. B., Aghayan, S. A., Agrawal, S., Ahmadi, A., Aichour, A. N., Aichour, I., Aichour, M. T. E., Al-Eyadhy, A., Al-Raddadi, R. M., Alahdab, F., Alene, K. A., Aljunid, S. M., ... et al (2019). Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017. The Lancet Respiratory Medicine, 7(1), 69-89. https://doi.org/10.1016/S2213-2600(18)30496-X

@article{70aa288392d3429ea3de7bb4957d0cfa,

title = "Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017",

abstract = "Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods: We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings: Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000–200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16{\^A}·4 deaths per 100 000 [95% UI 11{\^A}·6–21{\^A}·9]), and the highest rate among all ages was in eastern Europe (5{\^A}·2 per 100 000 population [95% UI 3{\^A}·5–7{\^A}·2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000–22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000–259 851 000). We estimated that 11{\^A}·5% (95% UI 10{\^A}·0–12{\^A}·9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000–73 864 000) episodes and 8 172 000 severe episodes (5 000 000–13 296 000). Interpretation: This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Funding: Bill & Melinda Gates Foundation.",

keywords = "World health, health surveys, influenza, respiratory infections",

author = "Troeger, {Christopher E.} and Blacker, {Brigette F.} and Khalil, {Ibrahim A.} and Zimsen, {Stephanie R. M.} and Albertson, {Samuel B.} and Degu Abate and Jemal Abdela and Adhikari, {Tara Ballav} and Aghayan, {Sargis Aghasi} and Sutapa Agrawal and Alireza Ahmadi and Aichour, {Amani Nidhal} and Ibtihel Aichour and Aichour, {Miloud Taki Eddine} and Ayman Al-Eyadhy and Al-Raddadi, {Rajaa M.} and Fares Alahdab and Alene, {Kefyalew Addis} and Aljunid, {Syed Mohamed} and Nelson Alvis-Guzman and Anber, {Nahla Hamed} and Mina Anjomshoa and Antonio, {Carl Abelardo T.} and Olatunde Aremu and Atalay, {Hagos Tasew} and Suleman Atique and Attia, {Engi F.} and Avokpaho, {Euripide F. G. A.} and Ashish Awasthi and Arefeh Babazadeh and Hamid Badali and Alaa Badawi and Banoub, {Joseph Adel Mattar} and Aleksandra Barac and Quique Bassat and Neeraj Bedi and Belachew, {Abate Bekele} and Bennett, {Derrick A.} and Krittika Bhattacharyya and Bhutta, {Zulfiqar A.} and Ali Bijani and Felix Carvalho and Casta{\~n}eda-Orjuela, {Carlos A.} and Christopher, {Devasahayam J.} and Lalit Dandona and Rakhi Dandona and Dang, {Anh Kim} and Ahmad Daryani and Degefa, {Meaza Girma} and Demeke, {Feleke Mekonnen} and Meghnath Dhimal and Shirin Djalalinia and Doku, {David Teye} and Manisha Dubey and Eleonora Dubljanin and Duken, {Eyasu Ejeta} and Dumessa Edessa and {El Sayed Zaki}, Maysaa and Hamed Fakhim and Eduarda Fernandes and Florian Fischer and Flor, {Luisa Sorio} and Foreman, {Kyle J.} and Gebremichael, {Teklu Gebrehiwo} and Demeke Geremew and Keyghobad Ghadiri and Goulart, {Alessandra C.} and Jingwen Guo and Ha, {Giang Hai} and Hailu, {Gessessew Bugssa} and Arvin Haj-Mirzaian and Arya Haj-Mirzaian and Samer Hamidi and Hassen, {Hamid Yimam} and Hoang, {Chi Linh} and Nobuyuki Horita and Mihaela Hostiuc and Irvani, {Seyed Sina Naghibi} and Jha, {Ravi Prakash} and Jonas, {Jost B.} and Amaha Kahsay and Andre Karch and Amir Kasaeian and Kassa, {Tesfaye Dessale} and Kefale, {Adane Teshome} and Khader, {Yousef Saleh} and Khan, {Ejaz Ahmad} and Gulfaraz Khan and Khan, {Md. Nuruzzaman} and Young-Ho Khang and Khoja, {Abdullah T.} and Jagdish Khubchandani and Kimokoti, {Ruth W.} and Adnan Kisa and Knibbs, {Luke D.} and Sonali Kochhar and Soewarta Kosen and Koul, {Parvaiz A.} and Ai Koyanagi and Defo, {Barthelemy Kaute} and Kumar, {G. Anil} and Lal, {Dharmesh Kumar} and Prabhat Lamichhane and Leshargie, {Cheru Tesema} and Miriam Levi and Shanshan Li and Macarayan, {Erlyn Rachelle King} and Marek Majdan and Varshil Mehta and Addisu Melese and Memish, {Ziad A.} and Mengistu, {Desalegn Tadese} and Meretoja, {Tuomo J.} and Tomislav Mestrovic and Bartosz Miazgowski and Milne, {George J.} and Branko Milosevic and Mirrakhimov, {Erkin M.} and Babak Moazen and Mohammad, {Karzan Abdulmuhsin} and Shafiu Mohammed and Lorenzo Monasta and Lidia Morawska and Mousavi, {Seyyed Meysam} and Muhammed, {Oumer Sada S.} and Srinivas Murthy and Ghulam Mustafa and Aliya Naheed and Nguyen, {Huong Lan Thi} and Nguyen, {Nam Ba} and Nguyen, {Son Hoang} and Nguyen, {Trang Huyen} and Nisar, {Muhammad Imran} and Nixon, {Molly R.} and Ogbo, {Felix Akpojene} and {et al}",

year = "2019",

doi = "10.1016/S2213-2600(18)30496-X",

language = "English",

volume = "7",

pages = "69--89",

journal = "The Lancet Respiratory Medicine",

issn = "2213-2619",

publisher = "The Lancet Publishing Group",

number = "1",

}

Troeger, CE, Blacker, BF, Khalil, IA, Zimsen, SRM, Albertson, SB, Abate, D, Abdela, J, Adhikari, TB, Aghayan, SA, Agrawal, S, Ahmadi, A, Aichour, AN, Aichour, I, Aichour, MTE, Al-Eyadhy, A, Al-Raddadi, RM, Alahdab, F, Alene, KA, Aljunid, SM, Alvis-Guzman, N, Anber, NH, Anjomshoa, M, Antonio, CAT, Aremu, O, Atalay, HT, Atique, S, Attia, EF, Avokpaho, EFGA, Awasthi, A, Babazadeh, A, Badali, H, Badawi, A, Banoub, JAM, Barac, A, Bassat, Q, Bedi, N, Belachew, AB, Bennett, DA, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Carvalho, F, Castañeda-Orjuela, CA, Christopher, DJ, Dandona, L, Dandona, R, Dang, AK, Daryani, A, Degefa, MG, Demeke, FM, Dhimal, M, Djalalinia, S, Doku, DT, Dubey, M, Dubljanin, E, Duken, EE, Edessa, D, El Sayed Zaki, M, Fakhim, H, Fernandes, E, Fischer, F, Flor, LS, Foreman, KJ, Gebremichael, TG, Geremew, D, Ghadiri, K, Goulart, AC, Guo, J, Ha, GH, Hailu, GB, Haj-Mirzaian, A, Haj-Mirzaian, A, Hamidi, S, Hassen, HY, Hoang, CL, Horita, N, Hostiuc, M, Irvani, SSN, Jha, RP, Jonas, JB, Kahsay, A, Karch, A, Kasaeian, A, Kassa, TD, Kefale, AT, Khader, YS, Khan, EA, Khan, G, Khan, MN, Khang, Y-H, Khoja, AT, Khubchandani, J, Kimokoti, RW, Kisa, A, Knibbs, LD, Kochhar, S, Kosen, S, Koul, PA, Koyanagi, A, Defo, BK, Kumar, GA, Lal, DK, Lamichhane, P, Leshargie, CT, Levi, M, Li, S, Macarayan, ERK, Majdan, M, Mehta, V, Melese, A, Memish, ZA, Mengistu, DT, Meretoja, TJ, Mestrovic, T, Miazgowski, B, Milne, GJ, Milosevic, B, Mirrakhimov, EM, Moazen, B, Mohammad, KA, Mohammed, S, Monasta, L, Morawska, L, Mousavi, SM, Muhammed, OSS, Murthy, S, Mustafa, G, Naheed, A, Nguyen, HLT, Nguyen, NB, Nguyen, SH, Nguyen, TH, Nisar, MI, Nixon, MR, Ogbo, FA & et al 2019, 'Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017', The Lancet Respiratory Medicine, vol. 7, no. 1, pp. 69-89. https://doi.org/10.1016/S2213-2600(18)30496-X

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017. / Troeger, Christopher E.; Blacker, Brigette F.; Khalil, Ibrahim A. et al.
In: The Lancet Respiratory Medicine, Vol. 7, No. 1, 2019, p. 69-89.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017

AU - Troeger, Christopher E.

AU - Blacker, Brigette F.

AU - Khalil, Ibrahim A.

AU - Zimsen, Stephanie R. M.

AU - Albertson, Samuel B.

AU - Abate, Degu

AU - Abdela, Jemal

AU - Adhikari, Tara Ballav

AU - Aghayan, Sargis Aghasi

AU - Agrawal, Sutapa

AU - Ahmadi, Alireza

AU - Aichour, Amani Nidhal

AU - Aichour, Ibtihel

AU - Aichour, Miloud Taki Eddine

AU - Al-Eyadhy, Ayman

AU - Al-Raddadi, Rajaa M.

AU - Alahdab, Fares

AU - Alene, Kefyalew Addis

AU - Aljunid, Syed Mohamed

AU - Alvis-Guzman, Nelson

AU - Anber, Nahla Hamed

AU - Anjomshoa, Mina

AU - Antonio, Carl Abelardo T.

AU - Aremu, Olatunde

AU - Atalay, Hagos Tasew

AU - Atique, Suleman

AU - Attia, Engi F.

AU - Avokpaho, Euripide F. G. A.

AU - Awasthi, Ashish

AU - Babazadeh, Arefeh

AU - Badali, Hamid

AU - Badawi, Alaa

AU - Banoub, Joseph Adel Mattar

AU - Barac, Aleksandra

AU - Bassat, Quique

AU - Bedi, Neeraj

AU - Belachew, Abate Bekele

AU - Bennett, Derrick A.

AU - Bhattacharyya, Krittika

AU - Bhutta, Zulfiqar A.

AU - Bijani, Ali

AU - Carvalho, Felix

AU - Castañeda-Orjuela, Carlos A.

AU - Christopher, Devasahayam J.

AU - Dandona, Lalit

AU - Dandona, Rakhi

AU - Dang, Anh Kim

AU - Daryani, Ahmad

AU - Degefa, Meaza Girma

AU - Demeke, Feleke Mekonnen

AU - Dhimal, Meghnath

AU - Djalalinia, Shirin

AU - Doku, David Teye

AU - Dubey, Manisha

AU - Dubljanin, Eleonora

AU - Duken, Eyasu Ejeta

AU - Edessa, Dumessa

AU - El Sayed Zaki, Maysaa

AU - Fakhim, Hamed

AU - Fernandes, Eduarda

AU - Fischer, Florian

AU - Flor, Luisa Sorio

AU - Foreman, Kyle J.

AU - Gebremichael, Teklu Gebrehiwo

AU - Geremew, Demeke

AU - Ghadiri, Keyghobad

AU - Goulart, Alessandra C.

AU - Guo, Jingwen

AU - Ha, Giang Hai

AU - Hailu, Gessessew Bugssa

AU - Haj-Mirzaian, Arvin

AU - Haj-Mirzaian, Arya

AU - Hamidi, Samer

AU - Hassen, Hamid Yimam

AU - Hoang, Chi Linh

AU - Horita, Nobuyuki

AU - Hostiuc, Mihaela

AU - Irvani, Seyed Sina Naghibi

AU - Jha, Ravi Prakash

AU - Jonas, Jost B.

AU - Kahsay, Amaha

AU - Karch, Andre

AU - Kasaeian, Amir

AU - Kassa, Tesfaye Dessale

AU - Kefale, Adane Teshome

AU - Khader, Yousef Saleh

AU - Khan, Ejaz Ahmad

AU - Khan, Gulfaraz

AU - Khan, Md. Nuruzzaman

AU - Khang, Young-Ho

AU - Khoja, Abdullah T.

AU - Khubchandani, Jagdish

AU - Kimokoti, Ruth W.

AU - Kisa, Adnan

AU - Knibbs, Luke D.

AU - Kochhar, Sonali

AU - Kosen, Soewarta

AU - Koul, Parvaiz A.

AU - Koyanagi, Ai

AU - Defo, Barthelemy Kaute

AU - Kumar, G. Anil

AU - Lal, Dharmesh Kumar

AU - Lamichhane, Prabhat

AU - Leshargie, Cheru Tesema

AU - Levi, Miriam

AU - Li, Shanshan

AU - Macarayan, Erlyn Rachelle King

AU - Majdan, Marek

AU - Mehta, Varshil

AU - Melese, Addisu

AU - Memish, Ziad A.

AU - Mengistu, Desalegn Tadese

AU - Meretoja, Tuomo J.

AU - Mestrovic, Tomislav

AU - Miazgowski, Bartosz

AU - Milne, George J.

AU - Milosevic, Branko

AU - Mirrakhimov, Erkin M.

AU - Moazen, Babak

AU - Mohammad, Karzan Abdulmuhsin

AU - Mohammed, Shafiu

AU - Monasta, Lorenzo

AU - Morawska, Lidia

AU - Mousavi, Seyyed Meysam

AU - Muhammed, Oumer Sada S.

AU - Murthy, Srinivas

AU - Mustafa, Ghulam

AU - Naheed, Aliya

AU - Nguyen, Huong Lan Thi

AU - Nguyen, Nam Ba

AU - Nguyen, Son Hoang

AU - Nguyen, Trang Huyen

AU - Nisar, Muhammad Imran

AU - Nixon, Molly R.

AU - Ogbo, Felix Akpojene

AU - et al, null

PY - 2019

Y1 - 2019

N2 - Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods: We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings: Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000–200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16Â·4 deaths per 100 000 [95% UI 11Â·6–21Â·9]), and the highest rate among all ages was in eastern Europe (5Â·2 per 100 000 population [95% UI 3Â·5–7Â·2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000–22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000–259 851 000). We estimated that 11Â·5% (95% UI 10Â·0–12Â·9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000–73 864 000) episodes and 8 172 000 severe episodes (5 000 000–13 296 000). Interpretation: This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Funding: Bill & Melinda Gates Foundation.

AB - Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods: We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings: Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000–200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16Â·4 deaths per 100 000 [95% UI 11Â·6–21Â·9]), and the highest rate among all ages was in eastern Europe (5Â·2 per 100 000 population [95% UI 3Â·5–7Â·2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000–22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000–259 851 000). We estimated that 11Â·5% (95% UI 10Â·0–12Â·9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000–73 864 000) episodes and 8 172 000 severe episodes (5 000 000–13 296 000). Interpretation: This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Funding: Bill & Melinda Gates Foundation.

KW - World health

KW - health surveys

KW - influenza

KW - respiratory infections

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:50726

U2 - 10.1016/S2213-2600(18)30496-X

DO - 10.1016/S2213-2600(18)30496-X

M3 - Article

SN - 2213-2619

SN - 2213-2600

VL - 7

SP - 69

EP - 89

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

IS - 1

ER -

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017

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