MQ-PGSTE : a new multi-quantum STE-based PGSE NMR sequence

S. Y. Kwun; Allan M. Torres; William S. Price

doi:10.1016/j.jmr.2009.03.004

MQ-PGSTE : a new multi-quantum STE-based PGSE NMR sequence

S. Y. Kwun, Allan M. Torres, William S. Price

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Abstract

A new multi-quantum stimulated echo based pulsed gradient spin-echo sequence, MQ-PGSTE, has been developed for measuring translational diffusion. The new sequence provides a higher signal-to-noise ratio than the (Hahn spin-echo based) MAXY-D sequence at long diffusion times, and thus potentially affords better diffusion measurements on macromolecule samples. Based on multi-quantum coherence encoding, the MQ-PGSTE sequence needs considerably lower gradient strengths for diffusion characterization compared to standard single quantum pulsed gradient spin-echo sequences. By using the new sequence, the diffusion coefficient of l-[3- 13C]-alanine was found to be 8.1 Â± 0.1 Ã— 10 -10 m 2 s -1, which is in line with the value obtained by the use of the standard stimulated echo based pulsed gradient spin-echo sequence.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Journal of Magnetic Resonance
Volume	Vol. 198
Issue number	No. 2
DOIs	https://doi.org/10.1016/j.jmr.2009.03.004
Publication status	Published - Jun 2009

Keywords

PGSE
diffusion
molecular dynamics
nuclear magnetic resonance
nuclear spin

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10.1016/j.jmr.2009.03.004

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title = "MQ-PGSTE : a new multi-quantum STE-based PGSE NMR sequence",

abstract = "A new multi-quantum stimulated echo based pulsed gradient spin-echo sequence, MQ-PGSTE, has been developed for measuring translational diffusion. The new sequence provides a higher signal-to-noise ratio than the (Hahn spin-echo based) MAXY-D sequence at long diffusion times, and thus potentially affords better diffusion measurements on macromolecule samples. Based on multi-quantum coherence encoding, the MQ-PGSTE sequence needs considerably lower gradient strengths for diffusion characterization compared to standard single quantum pulsed gradient spin-echo sequences. By using the new sequence, the diffusion coefficient of l-[3- 13C]-alanine was found to be 8.1 {\^A}± 0.1 {\~A}— 10 -10 m 2 s -1, which is in line with the value obtained by the use of the standard stimulated echo based pulsed gradient spin-echo sequence.",

keywords = "PGSE, diffusion, molecular dynamics, nuclear magnetic resonance, nuclear spin",

author = "Kwun, {S. Y.} and Torres, {Allan M.} and Price, {William S.}",

year = "2009",

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doi = "10.1016/j.jmr.2009.03.004",

language = "English",

volume = "Vol. 198",

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TY - JOUR

T1 - MQ-PGSTE : a new multi-quantum STE-based PGSE NMR sequence

AU - Kwun, S. Y.

AU - Torres, Allan M.

AU - Price, William S.

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N2 - A new multi-quantum stimulated echo based pulsed gradient spin-echo sequence, MQ-PGSTE, has been developed for measuring translational diffusion. The new sequence provides a higher signal-to-noise ratio than the (Hahn spin-echo based) MAXY-D sequence at long diffusion times, and thus potentially affords better diffusion measurements on macromolecule samples. Based on multi-quantum coherence encoding, the MQ-PGSTE sequence needs considerably lower gradient strengths for diffusion characterization compared to standard single quantum pulsed gradient spin-echo sequences. By using the new sequence, the diffusion coefficient of l-[3- 13C]-alanine was found to be 8.1 Â± 0.1 Ã— 10 -10 m 2 s -1, which is in line with the value obtained by the use of the standard stimulated echo based pulsed gradient spin-echo sequence.

AB - A new multi-quantum stimulated echo based pulsed gradient spin-echo sequence, MQ-PGSTE, has been developed for measuring translational diffusion. The new sequence provides a higher signal-to-noise ratio than the (Hahn spin-echo based) MAXY-D sequence at long diffusion times, and thus potentially affords better diffusion measurements on macromolecule samples. Based on multi-quantum coherence encoding, the MQ-PGSTE sequence needs considerably lower gradient strengths for diffusion characterization compared to standard single quantum pulsed gradient spin-echo sequences. By using the new sequence, the diffusion coefficient of l-[3- 13C]-alanine was found to be 8.1 Â± 0.1 Ã— 10 -10 m 2 s -1, which is in line with the value obtained by the use of the standard stimulated echo based pulsed gradient spin-echo sequence.

KW - PGSE

KW - diffusion

KW - molecular dynamics

KW - nuclear magnetic resonance

KW - nuclear spin

UR - http://handle.uws.edu.au:8081/1959.7/496543

U2 - 10.1016/j.jmr.2009.03.004

DO - 10.1016/j.jmr.2009.03.004

M3 - Article

SN - 1090-7807

VL - Vol. 198

SP - 271

EP - 274

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

IS - No. 2

ER -

MQ-PGSTE : a new multi-quantum STE-based PGSE NMR sequence

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