Abstract
The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has sparked interest in its role in colorectal cancer (CRC). To date, there is evidence indicating a relationship of MRN expression with reduced progression-free survival, although the significance of the MRN complex in the clinical setting remains controversial. In this review, we present an overview of the function of the MRN complex, its role in cancer progression, and current evidence in colorectal cancer. The evidence indicates that the MRN complex has potential utilisation as a biomarker and as a putative treatment target to improve outcomes of colorectal cancer.
| Original language | English |
|---|---|
| Article number | 816 |
| Number of pages | 11 |
| Journal | International Journal of Molecular Sciences |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2019 |
Open Access - Access Right Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Keywords
- DNA repair
- biochemical markers
- cancer
- colon (anatomy)
- prognosis
- rectum
