TY - JOUR
T1 - Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery
AU - Khursheed, R.
AU - Gulati, M.
AU - Wadhwa, S.
AU - Vishwas, S.
AU - Sharma, D.S.
AU - Corrie, L.
AU - Alam, A.
AU - Alnasser, S.M.
AU - Aba Alkhayl, F.F.
AU - Parveen, Z.
AU - Nammi, Srinivas
AU - Chellappan, D.K.
AU - Gupta, G.
AU - Zacconi, F.
AU - Steel, A.
AU - Adams, J.
AU - Jha, N.K.
AU - Dua, K.
AU - Singh, S.K.
PY - 2022
Y1 - 2022
N2 - Synbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.
AB - Synbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.
UR - https://hdl.handle.net/1959.7/uws:74780
U2 - 10.1016/j.cbi.2022.110223
DO - 10.1016/j.cbi.2022.110223
M3 - Article
SN - 0009-2797
VL - 368
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
M1 - 110223
ER -
