Mutations of mitochondrial genome in carotid atherosclerosis

Margarita A. Sazonova, Andrey V. Zhelankin, Valeria A. Barinova, Vasily V. Sinyov, Zukhra B. Khasanova, Anton Y. Postnov, Alexander N. Orekhov, Yuri V. Bobryshev, Igor A. Sobenin

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

With aim of detection the spectrum of mitochondrial DNA mutations in patients with carotid atherosclerosis from Moscow Region, we used a Roche 454 high-throughput sequencing of the whole mitochondrial genome. We have found that the presence of a number of homoplasmic mitochondrial DNA mutations in genes of 16S ribosomal RNA, subunits 2, 4, and 5 NADH dehydrogenase, subunits 1 and 2 cytochrome C oxidase, subunit 6 ATP-synthase, tRNA-Leu 2 and cytochrome B differed between conventionally healthy participants of the study and patients with carotid atherosclerosis. We also found heteroplasmic mutations, including insertions one or several nucleotides, that occurred more frequently in mitochondrial DNA of conventionally healthy participants of the study or patients with atherosclerotic lesions.
Original languageEnglish
Article number111
Number of pages6
JournalFrontiers in Genetics
Volume6
DOIs
Publication statusPublished - 2015

Open Access - Access Right Statement

© 2015 Sazonova, Zhelankin, Barinova, Sinyov, Khasanova, Postnov, Orekhov, Bobryshev and Sobenin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

  • atheroschlerosis
  • mitochondria
  • mitochondrial DNA
  • mutation (biology)
  • nucleotide sequence

Fingerprint

Dive into the research topics of 'Mutations of mitochondrial genome in carotid atherosclerosis'. Together they form a unique fingerprint.

Cite this