Abstract
With aim of detection the spectrum of mitochondrial DNA mutations in patients with carotid atherosclerosis from Moscow Region, we used a Roche 454 high-throughput sequencing of the whole mitochondrial genome. We have found that the presence of a number of homoplasmic mitochondrial DNA mutations in genes of 16S ribosomal RNA, subunits 2, 4, and 5 NADH dehydrogenase, subunits 1 and 2 cytochrome C oxidase, subunit 6 ATP-synthase, tRNA-Leu 2 and cytochrome B differed between conventionally healthy participants of the study and patients with carotid atherosclerosis. We also found heteroplasmic mutations, including insertions one or several nucleotides, that occurred more frequently in mitochondrial DNA of conventionally healthy participants of the study or patients with atherosclerotic lesions.
Original language | English |
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Article number | 111 |
Number of pages | 6 |
Journal | Frontiers in Genetics |
Volume | 6 |
DOIs | |
Publication status | Published - 2015 |
Open Access - Access Right Statement
© 2015 Sazonova, Zhelankin, Barinova, Sinyov, Khasanova, Postnov, Orekhov, Bobryshev and Sobenin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Keywords
- atheroschlerosis
- mitochondria
- mitochondrial DNA
- mutation (biology)
- nucleotide sequence