Nanoparticulate drug delivery to colorectal cancer : formulation strategies and surface engineering

Thao Truong-Dinh Tran; Phuong Ha-Lien Tran; Yichao Wang; Puwang Li; Lingxue Kong

doi:10.2174/1381612822666160217140932

Nanoparticulate drug delivery to colorectal cancer : formulation strategies and surface engineering

Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Yichao Wang, Puwang Li, Lingxue Kong

Western Sydney University

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining of specific properties for a real transition from laboratory to the clinical oral and parental administration. This review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are also highlighted.

Original language	English
Pages (from-to)	2904-2912
Number of pages	9
Journal	Current Pharmaceutical Design
Volume	22
Issue number	19
DOIs	https://doi.org/10.2174/1381612822666160217140932
Publication status	Published - 2016

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abstract = "The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining of specific properties for a real transition from laboratory to the clinical oral and parental administration. This review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are also highlighted.",

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AU - Li, Puwang

AU - Kong, Lingxue

PY - 2016

Y1 - 2016

N2 - The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining of specific properties for a real transition from laboratory to the clinical oral and parental administration. This review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are also highlighted.

AB - The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining of specific properties for a real transition from laboratory to the clinical oral and parental administration. This review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are also highlighted.

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ER -

Nanoparticulate drug delivery to colorectal cancer : formulation strategies and surface engineering

Abstract

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