TY - JOUR
T1 - New compounds based on a benzimidazole nucleus : synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines
AU - Akkoc, Senem
AU - Kayser, Veysel
AU - İlhan, İlhan Ãzer
AU - Hibbs, David E.
AU - Gok, Yetkin
AU - Williams, Peter A.
AU - Hawkins, Bryson
AU - Lai, Felcia
PY - 2017
Y1 - 2017
N2 - Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9.
AB - Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based complexes have been synthesized and their structures characterized with a number of different instrumental techniques including NMR (H-1 and C-13), IR, EI-MS (for 2), X-ray (for 1, 2 and 4) and elemental analysis. The cytotoxicity of all the compounds was tested using the human embryonic kidney (HEK-293T), human breast epithelial adenocarcinoma (MDA-MB-231), and human colon epithelial colorectal adenocarcinoma (DLD-1) cell lines. The benzimidazolium salts (2-5) had more cytotoxic activity against cancerous cells compared with the metal complexes (6-9), which curiously exhibited no activity against any of the cell lines. Based on the IC50 values, compound 5 displayed the highest in vitro anticancer activity among compounds 2-9.
UR - https://hdl.handle.net/1959.7/uws:63678
U2 - 10.1016/j.jorganchem.2017.03.037
DO - 10.1016/j.jorganchem.2017.03.037
M3 - Article
SN - 0022-328X
VL - 839
SP - 98
EP - 107
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
ER -
