No Direct Clinical Relevance of the Human Leucocyte Antigen (HLA) System in Clozapine-Induced Agranulocytosis

F. H.J. Claas; P. A. Abbott; M. D. Witvliet; J. D’Amaro; P. M. Barnes; P. Krupp

doi:10.2165/00002018-199200071-00004

No Direct Clinical Relevance of the Human Leucocyte Antigen (HLA) System in Clozapine-Induced Agranulocytosis

F. H.J. Claas
, P. A. Abbott
, M. D. Witvliet
, J. D’Amaro
, P. M. Barnes
, P. Krupp

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The clinical use of clozapine in psychiatry is restricted by the associated risk of agranulocytosis. This risk is significantly higher than that associated with conventional antipsychotic medications. In order to identify a possible parameter to detect susceptible individuals before treatment, 103 patients with a history of clozapine-induced granulocytopenia or agranulocytosis and 95 matched control patients were typed for human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and for a number of neutrophil-specific alloantigens. No significant association between certain HLA alleles or neutrophil antigens and susceptibility to clozapine-induced granulocytopenia or agranulocytosis was observed.

Original language	English
Pages (from-to)	3-6
Number of pages	4
Journal	Drug Safety
Volume	7
Issue number	1
DOIs	https://doi.org/10.2165/00002018-199200071-00004
Publication status	Published - Dec 1992
Externally published	Yes

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title = "No Direct Clinical Relevance of the Human Leucocyte Antigen (HLA) System in Clozapine-Induced Agranulocytosis",

abstract = "The clinical use of clozapine in psychiatry is restricted by the associated risk of agranulocytosis. This risk is significantly higher than that associated with conventional antipsychotic medications. In order to identify a possible parameter to detect susceptible individuals before treatment, 103 patients with a history of clozapine-induced granulocytopenia or agranulocytosis and 95 matched control patients were typed for human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and for a number of neutrophil-specific alloantigens. No significant association between certain HLA alleles or neutrophil antigens and susceptibility to clozapine-induced granulocytopenia or agranulocytosis was observed.",

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AU - Claas, F. H.J.

AU - Abbott, P. A.

AU - Witvliet, M. D.

AU - D’Amaro, J.

AU - Barnes, P. M.

AU - Krupp, P.

PY - 1992/12

Y1 - 1992/12

N2 - The clinical use of clozapine in psychiatry is restricted by the associated risk of agranulocytosis. This risk is significantly higher than that associated with conventional antipsychotic medications. In order to identify a possible parameter to detect susceptible individuals before treatment, 103 patients with a history of clozapine-induced granulocytopenia or agranulocytosis and 95 matched control patients were typed for human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and for a number of neutrophil-specific alloantigens. No significant association between certain HLA alleles or neutrophil antigens and susceptibility to clozapine-induced granulocytopenia or agranulocytosis was observed.

AB - The clinical use of clozapine in psychiatry is restricted by the associated risk of agranulocytosis. This risk is significantly higher than that associated with conventional antipsychotic medications. In order to identify a possible parameter to detect susceptible individuals before treatment, 103 patients with a history of clozapine-induced granulocytopenia or agranulocytosis and 95 matched control patients were typed for human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and for a number of neutrophil-specific alloantigens. No significant association between certain HLA alleles or neutrophil antigens and susceptibility to clozapine-induced granulocytopenia or agranulocytosis was observed.

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EP - 6

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JF - Drug Safety

IS - 1

ER -

No Direct Clinical Relevance of the Human Leucocyte Antigen (HLA) System in Clozapine-Induced Agranulocytosis

Abstract

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