Nocardioazines : a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

Ritesh Raju; Andrew Piggott; Xiao-Cong Huang; Robert Capon

doi:10.1021/ol200904v

Nocardioazines : a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

Ritesh Raju
, Andrew Piggott
, Xiao-Cong Huang
, Robert Capon

School of Medicine

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.

Original language	English
Pages (from-to)	2770-2773
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	10
DOIs	https://doi.org/10.1021/ol200904v
Publication status	Published - 2011

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SDG 3 Good Health and Well-being

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10.1021/ol200904v

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title = "Nocardioazines : a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein",

abstract = "An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.",

author = "Ritesh Raju and Andrew Piggott and Xiao-Cong Huang and Robert Capon",

year = "2011",

doi = "10.1021/ol200904v",

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T1 - Nocardioazines : a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

AU - Raju, Ritesh

AU - Piggott, Andrew

AU - Huang, Xiao-Cong

AU - Capon, Robert

PY - 2011

Y1 - 2011

N2 - An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.

AB - An Australian marine sediment-derived isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.

UR - http://handle.uws.edu.au:8081/1959.7/544889

U2 - 10.1021/ol200904v

DO - 10.1021/ol200904v

M3 - Article

C2 - 21513295

SN - 1523-7052

VL - 13

SP - 2770

EP - 2773

JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Nocardioazines : a novel bridged diketopiperazine scaffold from a marine-derived bacterium inhibits p-glycoprotein

Abstract

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